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"Ethical issues associated with the application of genetics for sport purposes are widely discussed and analyzed, anticipating the present possibilities of science. One could mention here works by Lippi et al. (2004), Miah (2002), Schneider and Friedmann (2006), and the aforementioned 'Genetics technology and sport – ethical questions' (Tamburrini and Tännsjö 2005). "
[Show abstract][Hide abstract] ABSTRACT: Competition is a natural part of human nature. Techniques and substances employed to enhance athletic performance and to achieve unfair success in sport have a long history, and there has been little knowledge or acceptance of potential harmful effects. Among doping practices, blood doping has become an integral part of endurance sport disciplines over the past decade. The definition of blood doping includes methods or substances administered for non-medical reasons to healthy athletes for improving aerobic performance. It includes all means aimed at producing an increased or more efficient mechanism of oxygen transport and delivery to peripheral tissues and muscles. The aim of this review is to discuss the biochemistry, physiology, and complications of blood doping and to provide an update on current antidoping policies.
[Show abstract][Hide abstract] ABSTRACT: Testosterone replacement therapy in hypogonadal men has been used for > 60 years. The use of testosterone substitution is continuously growing and is given to aging men to improve the quality of life. Because testosterone use is associated with muscle strength enhancing effects, it has become a popular drug to abuse. Doping with anabolic steroids, such as testosterone, is a severe challenge to the vision, moral and ethics in sports and has also become a significant and increasing problem in society.
The primary aim of this review is to summarize and discuss the contribution of genetic components to inter-individual variation in androgen disposition.
Genetic variation has a large impact on androgen disposition. This variation is of the utmost importance for the interpretation of doping test results and may modulate the effects of testosterone replacement therapy and testosterone doping.
Expert Opinion on Drug Metabolism & Toxicology 06/2009; 5(7):731-44. DOI:10.1517/17425250902976862 · 2.83 Impact Factor