Rovio, S. et al. Leisure time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol. 4, 705-711

Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden.
The Lancet Neurology (Impact Factor: 21.9). 12/2005; 4(11):705-11. DOI: 10.1016/S1474-4422(05)70198-8
Source: PubMed


Physical activity may help maintain cognitive function and decrease dementia risk, but epidemiological findings remain controversial. The aim of our study was to investigate the association between leisure-time physical activity at midlife and the subsequent development of dementia and Alzheimer's disease (AD).
Participants were randomly selected from the survivors of a population-based cohort previously surveyed in 1972, 1977, 1982, or 1987. 1449 persons (72.5%) age 65-79 years participated in the re-examination in 1998 (mean follow-up, 21 years). 117 persons had dementia and 76 had AD. Multiple logistic regression methods were used to analyse the association between leisure-time physical activity and dementia or AD.
Leisure-time physical activity at midlife at least twice a week was associated with a reduced risk of dementia and AD (odds ratio [OR] 0.48 [95% CI 0.25-0.91] and 0.38 [0.17-0.85], respectively), even after adjustments for age, sex, education, follow-up time, locomotor disorders, APOE genotype, vascular disorders, smoking, and alcohol drinking. The associations were more pronounced among the APOE epsilon4 carriers.
Leisure-time physical activity at midlife is associated with a decreased risk of dementia and AD later in life. Regular physical activity may reduce the risk or delay the onset of dementia and AD, especially among genetically susceptible individuals.

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    • "Relative to the outcome of Alzheimer's disease, Rovio et al. (2005) reported a significant interaction term with results indicating that the risk of Alzheimer's disease is significantly reduced for active carriers but that there is no effect of physical activity for noncarriers. Kivipelto et al. (2008) also reported that associations for Alzheimer's disease were stronger, but they do not share those results in the publication. "

    02/2015; 4(1):28-38. DOI:10.1123/kr.2014-0075
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    • "Grandparents have claimed that playing with and caring for their grandchildren provided them with a form of daily activity and exercise, helping them to feel youthful and alive [31] [32] [33]. As physical activity is known to influence cognition and dementia risk [34] [35] [36] [37] [38], it may contribute to the relationship between grandparenting and cognition. "
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    Maturitas 11/2014; 80(2). DOI:10.1016/j.maturitas.2014.10.017 · 2.94 Impact Factor
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    • "Khalil et al. (2013) have also shown a structured exercise program to be beneficial for patients with early to midstage HD, with improvements in gait speed, balance, and physical functioning. It has also been shown that leading a more active life (both physically and mentally) may protect against dementia and Alzheimer's disease (Fratiglioni et al. 2004; Verghese et al. 2003; Larson et al. 2006; Rovio et al. 2005), and delay the onset of HD (Trembath et al. 2010). Such lifestyle modifications can be simulated in laboratory animals through the provision of environmental enrichment (EE). "
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