Fluoroquinolone-resistant Vibrio cholerae isolated during cholera outbreak in India

Department of Microbiology, Karnataka Institute of Medical Sciences, Hubli 580022, India.
Transactions of the Royal Society of Tropical Medicine and Hygiene (Impact Factor: 1.84). 04/2006; 100(3):224-6. DOI: 10.1016/j.trstmh.2005.07.007
Source: PubMed


During the cholera epidemic of 2002 in and around Hubli, south India, Vibrio cholerae strains resistant to fluoroquinolones were isolated. Among the isolates of V. cholerae non-O1, non-O139 serogroups, 55.9% and 47.1% were resistant to norfloxacin and ciprofloxacin, respectively. However, only 12.5% of the O1 serogroup strains were resistant to both norfloxacin and ciprofloxacin. Though the O139 serogroup strains were susceptible to these antibiotics, they exhibited multidrug resistance. Emergence of fluoroquinolone-resistant V. cholerae that also exhibited multidrug resistance is of great significance in the epidemiology and control of cholera.

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    • "Non-O1 non-O139 serotypes of V. cholerae are increasingly being reported as the causal agents of severe gastrointestinal disorders (Chatterjee et al., 1998; Das & Gupta, 2005). And the isolation of multidrug-resistant clinical isolates has focused the need for a vaccine (Das & Gupta, 2005; Krishna et al., 2006). The choice of prospective vaccine targets is linked to immunodominant structures engaged in cholera pathogenesis (Kabir, 2005; Levine, 2010). "
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    FEMS Immunology & Medical Microbiology 03/2012; 65(3):422-30. DOI:10.1111/j.1574-695X.2012.00957.x · 3.08 Impact Factor
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    • "Most strains also showed resistance to streptomycin and nalidixic acid (Table 1). Such a complex resistance profile is quite common in Indian V. cholerae strains, known to be resistant to cotrimoxazole , beta-lactams, fluoroquinolones, and aminoglycosides as previously described (Thungapathra et al., 2002; Krishna et al., 2006). "
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    ABSTRACT: Integrative conjugative elements (ICEs) of the SXT/R391 family are self-transmissible mobile elements mainly involved in antibiotic resistance spread among γ-Proteobacteria, including Vibrio cholerae. We demonstrated that the recently described ICEVchInd5 is prevailing in V. cholerae O1 clinical strains isolated in Wardha province (Maharashtra, India) from 1994 to 2005. Genetic characterization by ribotyping and multiple-locus SSR analysis proved the same clonal origin for V. cholerae O1 isolates in Wardha province over an 11-year period and was used to assess the correlation between strain and ICE content among ours and different Indian reference strains. In silico analysis showed the existence of at least 3 sibling ICEs of ICEVchInd5 in V. cholerae O1 El Tor reference strains, isolated in the Indian subcontinent after 1992.
    International journal of medical microbiology: IJMM 04/2011; 301(4):318-24. DOI:10.1016/j.ijmm.2010.11.005 · 3.61 Impact Factor
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    • "Multiple antibiotic resistance among V. cholerae has emerged as a major problem worldwide (Faruque et al. 2007). In India, there is a progressive increasing trend of antibiotic resistance towards common fluoroquinolone, i.e., ciprofloxacin and norfloxacin since 1996 (Garg et al. 2001; Krishna et al. 2006). In this study, however, strains are sensitive to ciprofloxacin and norfloxacin but resistant to nalidixic acid, a non-fluorinated quinolone. "
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