Article

Helicases that interact with replication forks: new candidates from archaea.

Institute of Genetics, School of Biology, Queen's Medical Centre, University of Nottingham, Nottingham NG 72UH, UK.
Biochemical Society Transactions (impact factor: 3.71). 01/2006; 33(Pt 6):1471-3. DOI:10.1042/BST20051471 pp.1471-3
Source: PubMed

ABSTRACT Overcoming DNA replication fork blocks is essential for completing genome duplication and cell division. Archaea and eukaryotes drive replication using essentially the same protein machinery. Archaea may be a valuable resource for identifying new helicase components at advancing forks and/or in replication-restart pathways. As described here, these may be relevant to understanding genome instability in metazoans.

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Keywords

eukaryotes drive replication
 
genome duplication
 
metazoans
 
new helicase components
 
Overcoming DNA replication fork blocks
 
protein machinery