Relation of Blood Pressure to Risk of Incident Alzheimer’s Disease and Change in Global Cognitive Function in Older Persons

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
Neuroepidemiology (Impact Factor: 2.56). 02/2006; 26(1):30-6. DOI: 10.1159/000089235
Source: PubMed


To examine the relation of systolic and diastolic blood pressure to incident Alzheimer's disease (AD) and rate of cognitive change.
Longitudinal cohort study with annual clinical evaluations. At baseline, blood pressure was measured, apolipoprotein E (APOE) genotyping was performed, and medications were reviewed.
824 older Catholic clergy members without baseline dementia were recruited from across the United States. During a mean of about 6 years of observation, 151 persons developed AD. In a proportional hazards model adjusted for age, sex and education, neither systolic (relative risk = 0.995; 95% CI: 0.986, 1.004, p = 0.249) nor diastolic (relative risk = 1.000; 95% CI: 0.985, 1.015, p = 0.975) blood pressure was related to AD incidence. In mixed effects models, neither systolic nor diastolic blood pressure was related to level or to annual rate of change on a global measure of cognition. These results did not change in subsequent models that accounted for the use of medications with antihypertensive properties or for the possession of an APOE epsilon4 allele.
In a cohort of older persons with a majority taking medications with antihypertensive properties, we did not find a relationship between blood pressure and risk of AD or cognitive decline.

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    • "A diabetes study of the Japanese elderly reported that higher SBP at baseline is significantly associated with cognitive decline after 6 years (per 10 mm Hg increase, adjusted OR, 1.42) [35]. In contrast, a U.S. longitudinal cohort study of 824 older Catholic clergy (mean age, 75 years) reported that neither SBP nor DBP was related to AD incidence during a 6-year follow-up [37]. In the present study, SBP was associated with MCI in a logistic regression analysis, in concordance with some previous reports. "
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