Article

What's New in HIV/AIDS? Chemokine receptor antagonists: a new era of HIV therapy?

Department of Infectious Diseases, Medical Policlinic, Ludwig Maximilian University Munich, Pettenkoferstr. 8a, 80336 Munich, Germany.
Infection (impact factor: 2.66). 11/2005; 33(5-6):408-10. DOI:10.1007/s15010-005-6605-8 pp.408-10
Source: PubMed

ABSTRACT Chemokine receptors are essential for human immunodeficiency virus (HIV) cell entry. CXCR4 and CCR5 are the two most relevant receptors and by inhibition of each of them a delayed onset of disease could be achieved. As both receptors are used at different stages of disease due to the domination of different HIV strains, a dual blockage of CXCR4 and CCR5 could be highly valuable for inhibiting viral transmission and replication.

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Keywords

Chemokine receptors
 
CXCR4
 
delayed onset
 
different HIV strains
 
different stages
 
HIV
 
human immunodeficiency virus
 
inhibiting viral transmission
 
receptors
 
relevant receptors
 

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