Article

Risk of selecting K65R in anti retroviral-naive HIV-infected individuals with chronic hepatitis B treated with adefovir

University of Bonn, Bonn, North Rhine-Westphalia, Germany
AIDS (Impact Factor: 6.56). 12/2005; 19(17):2036-8. DOI: 10.1097/01.aids.0000189563.79976.05
Source: PubMed

ABSTRACT Seven antiretroviral-naive HIV-infected individuals with chronic hepatitis B treated with adefovir for longer than 6 months were assessed. Using bulk population sequencing and a sensitive limiting dilution analysis, the selection of K65R or other resistance mutations did not occur in HIV, suggesting that adefovir can be confidently used as hepatitis B virus (HBV) therapy in HIV/HBV-co-infected patients who do not require antiretroviral therapy.

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