Interest in the gastrointestinal (GI) factors of autistic disorder (autism) has developed from descriptions of symptoms such as constipation and diarrhea in autistic children and advanced towards more detailed studies of GI histopathology and treatment modalities. This review attempts to critically and comprehensively analyze the literature as it applies to all aspects of GI factors in autism, including discussion of symptoms, pathology, nutrition, and treatment. While much literature is available on this topic, a dearth of rigorous study was found to validate GI factors specific to children with autism.
"It is sometimes possible to identify physiological weaknesses that are the direct or indirect cause of certain behavioural and eating problems. These include impaired sensory-motor processing (Brisson, Warreyn, Serres, Foussier, & Adrien, 2011; Matson, Matson, & Beighley, 2011; Ming, Brimacombe, & Wagner, 2007; Overland, 2011; Provost, Lopez, & Heimerl, 2007), cognitive and emotional dysfunction (Nadon, 2011) and gastrointestinal disorders (Erickson et al., 2005; Goodwin, Cowen, & Goodwin, 1971; Souza et al., 2012; Wang, Tancredi, & Thomas, 2011). It is important that such conditions are not ignored because an exclusively behavioural approach to treatment in these cases can underrate the impact of organic problems on children's feeding habits (Hsu & Ho, 2009; Twachtman-Reilly, Amaral, & Zebrowski, 2008). "
[Show abstract][Hide abstract] ABSTRACT: We aimed to compare body mass index( BMI) and healthy eating index( HEI) in children
with autism spectrum disorder( ASD, n = 105) and typically developing (TD, n = 495)
children.They were aged 6–9years,lived in Valencia (Spain) and came from similar
cultural and socio-economic backgrounds.In this case–control study,the weight,height
and BMI were measured for both groups.Three-day food records were used to assess
dietary intake.Although the differences between children with ASD and TD children in raw
BMI (p = 0.44),BMI z-score (p = 0.37),HEI(p = 0.43)and total energy intake (p = 0.86) were
not significant,children with ASD and the boys subgroup were shorter (p = 0.01),but not
the girls subgroup,compared to TD children of the same gender.Using the controls values
as a reference,the BMI distribution in children with ASD be came distorted,with values
below the 5th percentile (11%vs.4%, p = 0.03) and above the 95th percentile (8%vs.5%,
p = 0.04).The gender-and age-adjusted odds ratios for being underweight in the groups of
all children and boys with ASD were 3.03 and 2.39,respectively,vs.TD children.Our data
suggest that routine monitoring of children with ASD should include anthropometric
measurements and assessment of their dietary habits
Research in Autism Spectrum Disorders 10/2014; 9(2015)26–33. DOI:10.1016/j.rasd.2014.09.013 · 2.96 Impact Factor
"Monosymptomatic enuresis nocturnal was diagnosed in the early years of the patient's life and was unsuccessfully treated in childhood with high doses of oxybutynin (5 mg/day). The patient did not have any bowel or other gastrointestinal problems typical of autism (Erickson et al. 2005; Levy et al. 2009). "
Journal of Child and Adolescent Psychopharmacology 10/2014; DOI:10.1089/cap.2014.0023 · 2.93 Impact Factor
"The proposition is that, as a result of gastrointestinal inflammation, also causing gastrointestinal symptoms (GIS), the normal barrier to peptide absorption from the gut is compromised. Increased rates (22–70%) of GIS have been reported in autism spectrum disorder (ASD) [Chandler et al., 2013; Erickson et al., 2005; Gorrindo et al., 2012; Horvath & Perman, 2002; Smith, Farnworth, Wright, & Allgar, 2009; Valicenti- McDermott et al., 2006; Wang, Tancredi, & Thomas, 2011], a variability that may depend on the sample (clinical or population-derived); the type, definition, and number of symptoms; the method of investigation employed; and whether symptoms are current or lifetime. The GIS most commonly reported in ASD are diarrhea "
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