Article

Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women.

Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA.
American Journal of Hypertension (impact factor: 3.18). 12/2005; 18(11):1388-95. DOI:10.1016/j.amjhyper.2005.05.023
Source: PubMed

ABSTRACT Left ventricular (LV) hypertrophy is a significant risk factor for cardiovascular disease. Given sex-based differences in cardiac structure and remodeling, we hypothesized that variation in estrogen pathway genes might be associated with alteration of LV structure.
We studied 1249 unrelated individuals, 547 men and 702 women (mean age 59 years) from the Framingham Heart Study. Eight single nucleotide polymorphisms in the genes for estrogen receptor alpha and estrogen receptor beta (ESR2) were tested for association with 5 LV measures: LV mass (LVM), LV wall thickness (LVWT), LV internal diameter at end-diastole and end-systole, and fractional shortening. Sex-specific multiple regression analyses were performed adjusting for age, weight, height, systolic and diastolic blood pressure, hypertension treatment, diabetes, and in women, menopausal status.
In men, there was no evidence of association between the estrogen pathway polymorphisms tested and LV structure or function. In women, however, two polymorphisms, ESR2 rs1256031 and ESR2 rs1256059, in linkage disequilibrium with one another, were associated with LVM and LVWT (P = .0007 to .03); the association was most pronounced in those women with hypertension (P = .0006 to .01). The association did not appear to be explained by variation in blood pressure, plasma lipoprotein levels, or hyperglycemia.
The ESR2 polymorphisms are associated with LV structural differences in women with hypertension in a community-based population. These data are consistent with the hypothesis that genetic factors may mediate part of the observed sex-based differences in LV structure and remodeling.

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Keywords

age 59 years
 
blood pressure
 
cardiac structure
 
cardiovascular disease
 
community-based population
 
diastolic blood pressure
 
ESR2 polymorphisms
 
estrogen pathway polymorphisms
 
estrogen receptor alpha
 
estrogen receptor beta
 
Left ventricular
 
LV internal diameter
 
LV mass
 
LV structural differences
 
LV structure
 
LV wall thickness
 
observed sex-based differences
 
plasma lipoprotein levels
 
sex-based differences
 
single nucleotide polymorphisms