Article

Nitric oxide is a signaling molecule that regulates gene expression

College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.
Methods in Enzymology (Impact Factor: 2.19). 02/2005; 396:326-40. DOI: 10.1016/S0076-6879(05)96027-8
Source: PubMed

ABSTRACT Nitric oxide (NO) is a dynamic and bioreactive molecule that can both participate in and inhibit the genesis of disease. Its ability to have an impact on a wide range of physiological events stems from its capacity to reversibly alter the expression of specific genes and the activities of a wide range of proteins and signaling pathways. Yet, NO* remains an enigmatic molecule. Recently developed technologies, including gene-chips, two-dimensional electrophoresis, RNA interference, matrix-assisted laser desorption ionization (MALDI)-TOF (time-of-flight) mass spectrometry, and protein arrays will allow us to better understand how NO* and associated reactive nitrogen species (RNS) regulate both physiology and disease states, toward the development of treatments using NO* synthase inhibitors or NO* donors.

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