Nanoparticles of Biodegradable Polymers for New-Concept Chemotherapy

Department of Chemical and Biomolecular Engineering, Faculty of Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260.
Expert Review of Medical Devices (Impact Factor: 1.68). 10/2004; 1(1):115-25. DOI: 10.1586/17434440.1.1.115
Source: PubMed


The current regimen of chemotherapy is far from satisfactory--its efficiency is limited and patients suffer from serious side effects. Various drug delivery devices have been under intensive investigation in the past few decades in attempts to develop controlled and targeted methods of chemotherapy administration. This article reviews the latest developments in nanoparticles of biodegradable polymers for chemotherapy of cancer and other diseases such as cardiovascular restenosis. The preliminary results obtained in the author's laboratory are used to demonstrate the concept. This review is written with the belief that engineering, in particular, chemical engineering principles, can be applied and further developed to solve the problems in the current practice of chemotherapy and promote a new concept of chemotherapy - chemotherapy at home.

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    • "At present, anticancer drugs development is in demand because of the controlled release after their administration in the body to a better treatment and patient compliance. Stimuli reactive biodegradable polymeric nanoparticles have become the keen interest of scientists in recent years due to their fascinated delivery of the drugs in a controlled manner [16]. These stimuli reactive polymeric systems have established precise advantages in the treatment of world's life threatening diseases and also in the release of vaccines [17] [18]. "
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    ABSTRACT: Cytotoxic drugs are a diverse class of compounds that treat cancer primarily by killing cancerous cells that are rapidly growing and dividing along with cells that are meant for normal tissue function. A novel and suitable delivery system delivers the chemotherapeutic agents to cancerous tissues without harming healthy tissues and also retains these chemotherapeutic agents in the tumor area for a longer period of time that gives a boost to the therapy. Smaller size increases the surface area of the nanoparticles that enhances drug absorption or encapsulation and carries the drug into the blood in a shorter time period. In comparison with already existing delivery systems, nano sized delivery systems can penetrate much deeper into tumor tissue, generally taken up more efficiently by cells and reduce the toxicity of cancerous drug to healthy tissues. However, nanoparticulate systems are being researched throughout the world to increase the drug efficacy and to reduce toxicity. Thus, generally nanoparticulate systems work on passive targeting as well as on active targeting of the drug to the tumors. However, the research is still at a nascent stage and there is a need to understand the role of nano carriers in cancer treatment. This article summarizes various drug delivery technologies for chemotherapeutic agents, which are gaining more attention for better therapeutic response.
    Frontiers in Anti-Cancer Drug Discovery, VOLUME: 3 edited by Editor(s): Atta-ur-Rahman Co-Editor(s): M. Iqbal Choudhary, 05/2014: chapter Novel Strategies in the Drug Delivery Development of Anticancer Drugs: The Nanoparticulate Formulations: pages 233-261 (29); Bentham Science Publishers., ISBN: 978-1-60805-885-3
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    • "In engineered nanomaterials, size is a crucial factor that regulates the circulation and navigation of nanomaterials in the bloodstream, penetration across the physiological drug barriers, site-and cell-specific localization and even induction of cellular responses (Feng, 2004; Ferrari, 2008; Jiang et al., 2008). In general, the size of a nonspherical nanomaterial is defined as an equivalent diameter of a spherical particle whose selected physical properties, e.g. "
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    ABSTRACT: Advances in nanotechnology have opened up a new era of diagnosis, prevention and treatment of diseases and traumatic injuries. Nanomaterials, including those with potential for clinical applications, possess novel physicochemical properties that have an impact on their physiological interactions, from the molecular level to the systemic level. There is a lack of standardized methodologies or regulatory protocols for detection or characterization of nanomaterials. This review summarizes the techniques that are commonly used to study the size, shape, surface properties, composition, purity and stability of nanomaterials, along with their advantages and disadvantages. At present there are no FDA guidelines that have been developed specifically for nanomaterial based formulations for diagnostic or therapeutic use. There is an urgent need for standardized protocols and procedures for the characterization of nanoparticles, especially those that are intended for use as theranostics.
    Biotechnology advances 11/2013; 32(4). DOI:10.1016/j.biotechadv.2013.11.006 · 9.02 Impact Factor
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    • "In recent years the nanotechnology has created one of the fast growing research fields in the pharmaceutical science [1] [2]. Many scientific groups have focused their research interests in synthesis and characterization of drug delivery formulations with shapes and sizes spanning within the nanometer scale range [3] [4]. The investigators' efforts involve elaboration of new synthetic methods, improvement of the stability of drug carriers, and their drug release properties for better targeting to the recipient cells and tissues [5] [6] [7]. "
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    ABSTRACT: Copolymer (vinyl acetate (VA)-co-3-dimethyl(methacryloyloxyethyl)ammonium propane sulfonate (DMAPS)) nanoparticles have been synthesized by radical copolymerization in water. It was established that the variation of the initial monomer feed (DMAPS concentration was 10 mol% (copolymer 1) and 90 mol% (copolymer 2)) changes the copolymerization type, nanoparticles morphology, self-organization and size distribution. The shape, average diameter, size distribution and zeta potential of the copolymer nanoparticles are determined by atomic force microscopy (AFM), dynamic light scattering and zeta potential data, respectively. While the copolymer 1 nanoparticles are solid with spherical shape, average diameter 276 nm and zeta potential −25.2 mV, the copolymer 2 nanoparticles have bean-like shapes with an average diameter 49.3 nm and zeta potential −4.4 mV and contain many domains with different density. For the first time the AFM images of the copolymer 2 nanoparticles presented the unique self-organization of the dipole–dipole clusters of DMAPS units. The results indicated that the obtained copolymer nanoparticles with specific structure could be used as drug delivery systems.
    European Polymer Journal 03/2013; 49(3):637–645. DOI:10.1016/j.eurpolymj.2012.12.003 · 3.01 Impact Factor
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