Article

A single adrenocorticotropic hormone stimulation test does not reveal adrenal insufficiency in septic shock.

Department of Intensive Care, Päijät-Häme Central Hospital, Keskussairaalankatu 7, Fin--15900 Lahti, Finland.
Anesthesia & Analgesia (impact factor: 3.29). 01/2006; 101(6):1792-8. DOI:10.1213/01.ANE.0000184042.91452.48 pp.1792-8
Source: PubMed

ABSTRACT The diagnosis of adrenocortical insufficiency in critically ill patients is complex. The adrenocorticotropic hormone (ACTH) stimulation test is a widely accepted method for assessing the adequacy of adrenal function in intensive care units, but it is possible that there may be wide variations in responses to the test over a short period of time. In this prospective study, we investigated the reproducibility of the ACTH stimulation test in 20 patients with sepsis, in 20 patients with septic shock, and in 20 critically ill patients without sepsis. Two consecutive ACTH stimulation tests were performed within 24 h after intensive care unit admission or at the onset of sepsis. In patients without sepsis there was good correlation between ACTH responses on days 1 and 2 (Pearson's correlation coefficient, 0.689; P = 0.001). In contrast, in patients with septic shock no correlation was observed between the two ACTH responses (Pearson's correlation coefficient, 0.401; P = 0.080). We conclude that the results of the ACTH stimulation tests are poorly reproducible in septic shock and a single ACTH stimulation test may not be the best method to diagnose adrenal insufficiency in these patients.

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Keywords

accepted method
 
ACTH
 
ACTH responses
 
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ACTH stimulation tests
 
adequacy
 
adrenal function
 
consecutive ACTH stimulation tests
 
critically ill patients
 
days 1
 
diagnose adrenal insufficiency
 
intensive care unit admission
 
intensive care units
 
Pearson's correlation coefficient
 
prospective study
 
septic shock
 
short period
 
single ACTH stimulation test
 
two ACTH responses