Production of natural methyl anthranilate by microbial N-demethylation of N-methyl methyl anthranilate by the topsoil-isolated bacterium Bacillus megaterium.

Marcus Taupp, Dag Harmsen, Frank Heckel, Peter Schreier

Lehrstuhl für Lebensmittelchemie, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany.

Journal Article: Journal of Agricultural and Food Chemistry (impact factor: 2.47). 12/2005; 53(24):9586-9. DOI: 10.1021/jf0521395

Abstract

Bacillus megaterium, isolated in a screening process from topsoil, was used for N-demethylation of natural N-methyl methyl anthranilate to produce natural methyl anthranilate. Maximal productivity of 70 mg/L/day was achieved under laboratory-scale conditions without further optimization. No byproducts were observed. Thus, production of "natural" methyl anthranilate using B. megaterium is a significant improvement over comparable already existing procedures.

Source: PubMed

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Keywords

byproducts
 
laboratory-scale conditions
 
methyl anthranilate
 
N-demethylation
 
natural methyl anthranilate
 
natural N-methyl methyl anthranilate
 
procedures
 
screening process
 
topsoil