Article

Performance on neurocognitive tests by co-twins to dementia cases compared to normal control twins.

Department of Psychology, University of Southern California, Los Angeles 90089-1061, USA.
Journal of Geriatric Psychiatry and Neurology (impact factor: 3.07). 01/2006; 18(4):202-7. DOI:10.1177/0891988705281865 pp.202-7
Source: PubMed

ABSTRACT Nondemented co-twins of twins who were diagnosed as demented were compared to randomly selected members of normal control twin pairs in which both members of the pair were nondemented. Nondemented co-twins included 23 monozygotic and 62 dizygotic twins; there were 27 normal control twins. Both monozygotic and dizygotic nondemented co-twins of dementia cases scored significantly lower than normal control twins on 5 of 10 cognitive tests. Moreover, monozygotic co-twins of dementia cases had a generally lower score profile than dizygotic co-twins of dementia cases did. These findings show that being at greater genetic risk for dementia is reflected in cognitive performance even in the absence of a diagnosis of dementia.

0 0
 · 
0 Bookmarks
 · 
31 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

10 cognitive tests
 
23 monozygotic
 
62 dizygotic twins
 
cognitive performance
 
dementia
 
dementia cases
 
dizygotic co-twins
 
dizygotic nondemented co-twins
 
greater genetic risk
 
lower
 
lower score profile
 
monozygotic co-twins
 
Nondemented co-twins
 
normal control twin pairs
 
normal control twins
 
twins