Article

A salivary malignant myoepithelioma in a dog.

ICBAS, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto Largo Prof. Abel Salazar, No. 2, 4099-003 Porto, Portugal.
The Veterinary Journal (impact factor: 2.24). 02/2007; 173(1):223-6. DOI:10.1016/j.tvjl.2005.08.018 pp.223-6
Source: PubMed

ABSTRACT Salivary tumours are uncommon in domestic animals and there are no known previous confirmed reports of salivary tumours of myoepithelial origin in dogs. A 12-year-old female mixed breed dog was presented with a lobulated mass, composed of white-yellowish tissues, extending from soft palate to epiglottis. Histological examination revealed a neoplastic lesion consisting of a dense population of cells showing moderate pleomorphism, with pale cytoplasm and large oval nuclei, arranged in solid lobules. Mitotic activity was very high. Tumoral cells were negative for both periodic acid-Schiff reaction and Alcian blue stain and displayed strong immunohistochemical reactivity for pan-cytokeratin, muscle specific actin and myosin and focal positivity for cytokeratin 14. On the basis of the morphological, histochemical and immunohistochemical findings a diagnosis of malignant tumour of myoepithelial origin (malignant myoepithelioma) was made.

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Keywords

12-year-old female mixed breed dog
 
dense population
 
dogs
 
domestic animals
 
focal positivity
 
Histological examination
 
immunohistochemical findings
 
malignant myoepithelioma
 
malignant tumour
 
Mitotic activity
 
moderate pleomorphism
 
muscle specific actin
 
myoepithelial origin
 
pale cytoplasm
 
periodic acid-Schiff reaction
 
reports
 
soft palate
 
solid lobules
 
strong immunohistochemical reactivity
 

A.M. Faustino