The psychological impact of mild ovarian stimulation combined with single embryo transfer compared with conventional IVF

Department of Medical Psychology and Psychotherapy, Erasmus Universiteit Rotterdam, Rotterdam, South Holland, Netherlands
Human Reproduction (Impact Factor: 4.57). 04/2006; 21(3):721-7. DOI: 10.1093/humrep/dei395
Source: PubMed


The objective of this study was to assess the psychological implications of mild ovarian stimulation combined with single embryo transfer (SET) during a first IVF cycle.
We conducted a randomized controlled two-centre trial. Three hundred and ninety-one couples were randomized to undergo either mild ovarian stimulation with GnRH antagonist co-treatment and SET (n=199) or conventional GnRH agonist long protocol ovarian stimulation with double embryo transfer (DET) (n=192). Women completed the Hospital Anxiety and Depression Scale, the Hopkins Symptom Checklist and the Subjective Sleep Quality Scale at baseline, on the first day of ovarian stimulation and following embryo transfer. Affect was assessed daily with the Daily Record Keeping Chart from the first day of ovarian stimulation until the day treatment outcome became known.
The conventional IVF group experienced elevated levels of physical and depressive symptoms during pituitary downregulation. At oocyte retrieval, this group experienced more positive affect and less negative affect than the mild IVF group. In the conventional IVF group, cycle cancellation was associated with less positive and more negative affect.
During the first IVF treatment cycle, mild ovarian stimulation and SET does not lead to more psychological complaints than conventional IVF.

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Article: The psychological impact of mild ovarian stimulation combined with single embryo transfer compared with conventional IVF

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    • "IVF is usually the final treatment option for infertile couples, and failure will probably mean their remaining childless38. It is therefore not surprising that both patients and men always demonstrate elevated levels of anxiety during IVF treatment3940. In IVF treatment, the state anxiety is caused by the fear of TVOR, or the strain of the emotional moment at ET, which can be measured by the levels of anxiety at a certain time-point41. "
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    • "Yet, conventional IVF regimes are not without side effects and risks. One of the risks associated with a conventional IVF protocol is ovarian hyperstimulation syndrome (OHSS), which although rare, is potentially life threatening (approximately one death in 400–500 000 cycles) (de Klerk et al., 2006; Heijnen et al., 2007; Devroey et al., 2009). Further side effects which can occur alongside the down-regulation necessary for conventional treatment protocols include abdominal discomfort, depressed mood, headaches, and lower back pain and muscular pain (de Klerk et al., 2006; Pennings and Ombelet, 2007). "
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