Article

Furans, thiophenes and related heterocycles in drug discovery.

Dartmouth College, Department of Chemistry, Hanover, NH 03755, USA.
Current opinion in drug discovery & development (impact factor: 4.2). 12/2005; 8(6):723-40. pp.723-40
Source: PubMed

ABSTRACT The five-membered aromatic heterocycles containing oxygen and sulfur are key building blocks used in medicinal chemistry applications. Furans, thiophenes and related azole analogs constitute an important class of compounds that are readily available, stable and easily functionalized. In this review, the authors survey the recent literature and highlight the application of such compounds in the development of therapeutic agents. This review focuses on two major strategies involving these compounds. The first is the use of these rings as intact scaffolds within the final target compound, and the second is the use of these compounds as convenient and flexible synthons for non-aromatic structural moieties.

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Keywords

available
 
azole analogs
 
final target compound
 
five-membered aromatic heterocycles
 
flexible synthons
 
functionalized
 
intact scaffolds
 
major strategies
 
medicinal chemistry applications
 
non-aromatic structural moieties
 
recent literature
 
therapeutic agents
 

Jeffrey B Sperry