Stabilization of Carotid Atheroma Assessed by Quantitative Ultrasound Analysis in Nonhypercholesterolemic Patients With Coronary Artery Disease

Kumamoto University, Kumamoto, Kumamoto, Japan
Journal of the American College of Cardiology (Impact Factor: 15.34). 12/2005; 46(11):2022-30. DOI: 10.1016/j.jacc.2005.04.070
Source: PubMed

ABSTRACT Several large clinical trials have demonstrated that lipid-lowering therapy with statins reduces cardiovascular events (1, 2 and 3). Stabilization rather than regression of vulnerable atheroma is considered the major contributor to this beneficial effect (4). Recent detailed animal studies support the plaque stabilization hypothesis (5); however, clinical evidence of plaque stabilization is uncertain and there are no practical indexes to assess the effectiveness of plaque stabilization therapy. Hence it is difficult for physicians to verify achievement of plaque stabilization and to be able to assess the efficacy of the treatment given their patients. Some hope in this area derives from recent technologic advances that can assist in the evaluation of atherosclerotic plaque vulnerability, such as plaque temperature (6), intravascular angioscopy (7), intravascular ultrasound (8), and optical-coherence tomography (9), but these methods are generally complicated, invasive, expensive, and hardly repeatable. Because plaque stabilization is a promising clinical strategy to prevent cardiovascular complications in patients with established coronary artery disease (CAD) (4), practical and feasible examinations to identify vulnerable plaques and to evaluate the effects of treatment on plaque stabilization are needed.

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Available from: Yoko Horibata, Aug 25, 2015
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