Article

Can 1000 Reviews Be Wrong? Actin, α-Catenin, and Adherens Junctions

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Cell (Impact Factor: 33.12). 01/2006; 123(5):769-72. DOI: 10.1016/j.cell.2005.11.009
Source: PubMed

ABSTRACT Coupling between cell adhesion and the actin cytoskeleton is thought to require a stable link between the cadherin-catenin complex and actin that is mediated by alpha-catenin. In this issue of Cell, the Weis and Nelson groups call this static model into question, showing that alpha-catenin can directly regulate actin dynamics (Drees et al., 2005 and Yamada et al., 2005).

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