Synchronous adenocarcinoma and carcinoid tumor of the terminal ileum in a Crohn's disease patient

Department of Surgery, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, Italy.
BMC Cancer (Impact Factor: 3.36). 02/2005; 5(1):157. DOI: 10.1186/1471-2407-5-157
Source: PubMed


Several malignancies have been described in association with inflammatory bowel diseases, the most common being adenocarcinoma. Carcinoid tumor and Crohn disease has also been previously reported, however the coexistence of both neoplasms is quite rare and the clinical diagnosis is very difficult. Here we report what we believe to be the fourth case of a mixed adenocarcinoid tumor coexisting with Crohn's disease.
The patient presented with clinical and radiological features of intestinal obstruction. Laparotomy showed a stricturing lesion in the last 6 cm of the terminal ileum with proximal dilation. Only the histology of the resected surgical specimen proved the presence of a mixed adenocarcinoid tumor involving the terminal ileum.
Carcinoid tumor should be suspected in elderly patients with Crohn's disease presenting with intestinal obstruction and laparotomy should be considered to exclude malignancy.

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    • "Patients in this study had a past history of various malignancies such as breast cancer, endometrial adenocarcinoma, colon adenocarcinoma, thyroid papillary carcinoma and malignant melanoma [9]. Primary carcinoid tumors found in combination with different types of tumors in other organs, such as in kidney or colon, have been reported in several studies [10-13]. However, a case about carcinoid tumors found in combination with different types of tumor within a lung has never been reported. "
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