Epidemiology of cerebral palsy

Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, P.O. Box 855, West Perth, WA 6872, Australia.
Seminars in Fetal and Neonatal Medicine (Impact Factor: 3.13). 05/2006; 11(2):117-25. DOI: 10.1016/j.siny.2005.10.010
Source: PubMed

ABSTRACT The term cerebral palsy refers to a range of clinical symptoms, with related service requirements, resulting from lesions or abnormalities in the brain arising early in life. It is not a diagnosis; aetiology and pathology are variable. This article discusses the definition and differential classification of cerebral palsy, describes trends in its frequency over time stratified by associated variables, and briefly reviews the most recent findings concerning its aetiology. (c) 2005 Elsevier Ltd. All rights reserved.

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    Pesquisa Brasileira em Odontopediatria e Clínica Integrada 03/2012; 12(1):127-133. DOI:10.4034/PBOCI.2012.121.20
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    ABSTRACT: Today, perinatal audit focuses basically on cases of perinatal mortality. In most centres in Western Europe, perinatal mortality is low. Identification of metabolic acidosis at birth may increase index cases eligible for evaluation of perinatal care, and this might improve quality of perinatal audit. The aim of this study is to assess the incidence of metabolic acidosis at birth in order to estimate its impact on perinatal audit. Cord blood was analysed for every neonate born between January 1, 2010 and December 31, 2012 in Ziekenhuis Oost-Limburg, Genk. Acidosis was defined as an umbilical arterial pH ≤ 7.05 with or without a venous pH ≤ 7.17. Respiratory acidosis (RA) was defined as acidosis with normal base excess, and metabolic acidosis (MA) was defined as acidosis with an arterial or venous base excess ≤ -10 mmol/L. In case of failed cord blood sampling, 5 minute Apgar score ≤ 6 was considered as the clinical equivalent of MA. Retrospective chart review of obstetric and paediatric files was performed for all cases of MA, together with review of paediatric follow-up charts from at least 6 months after birth. Perinatal asphyxia was defined as biochemical evidence for MA at birth, associated with early onset neonatal encephalopathy and long-term symptoms of cerebral palsy. In a total of 6614 babies, perinatal death up to 7 days of life occurred in 40 babies (6.0‰). Acidosis was present in 183 neonates (2.8%), of which 130 (2.0%) had RA and 53 (0.8%) had MA. Of the 173 neonates with unknown pH values, 6 had Apgar scores ≤ 6. Of 59 babies born with MA or its clinical equivalent, 52 (88.1%) showed no neurologic symptoms at birth. Two (3.4%) died in the early neonatal period, one after abruptio placentae and one due to chorioamnionitis and severe prematurity. Five (8.5%) MA babies had symptoms of early onset neonatal encephalopathy, which recovered in three (5.1%), and persisted long-term in two others (3.4%). The two babies with cerebral palsy (prevalence 1/3300) were both born after instrumental vaginal delivery for foetal distress. In our study cohort, the incidence of perinatal mortality is 6‰. The incidence of metabolic acidosis is 9‰. Addition of cases of metabolic acidosis to those of mortality doubles index cases eligible for perinatal audit. The incidence of babies surviving with cerebral palsy after metabolic acidosis at birth is very low (0.3‰). Our results suggest that instrumental delivery for foetal distress might be a risk factor for metabolic acidosis with persisting neurologic dysfunction. Our study illustrates that identification of peripartum near-miss is useful for perinatal audit.
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    ABSTRACT: INTRODUCTION: infantile cerebral palsy (ICP) is a series of disorders of the development of the movement and the position, due to a cerebral injury in the fetal period or first years. OBJECTIVE: to compare the overburden of the carer with the degree of deterioration and the number of comorbidities that present the patients with infantile cerebral palsy (ICP). METHODS: it was made a descriptive Cross-Sectional study in which, previous clinical and epidemiological characterization of the cases of PCI seen at the Hospital Infantil Napoleon Franco Pareja (HINFP) in the period between January 2010 and December 2011 through revision of the corresponding clinical histories, it was applied to the main carers of those patients the survey developed by Zarit et all., for the determination of the perceived burden due to the care of the patients and subsequent correlation of these with the characteristics of the patients. Data was saved in database Excel and they were analyzed by means of the statistic program EPI INFO version 3.5.1. RESULTS: there were identified 66 patients and their carers to whom it was applied the survey of Zarit. All carers are from socioeconomic stratum 1 and with incomplete basic educational level. As for to the patients with PCI: Mean age was 6.4 years old, 40.9% of female gender and 59.1% male, with the majority of urban areas (80.3%). The type of palsy found was Spastic with 78.8% of the cases, followed by hypotonic 9.1%. 43.9% of the patients had as associated diagnosis epilepsy. 12.1% presented 3 or more comorbidities. The presence of multiple comorbidities was associated to the presence of excessive burden of the carer (p=0.001). CONCLUSIONS: the more frequent type of PCI was spastic palsy. To higher number of comorbidities, higher the overburden of the carers. Rev.cienc.biomed. 2012;3(2): 242-248