The term cerebral palsy refers to a range of clinical symptoms, with related service requirements, resulting from lesions or abnormalities in the brain arising early in life. It is not a diagnosis; aetiology and pathology are variable. This article discusses the definition and differential classification of cerebral palsy, describes trends in its frequency over time stratified by associated variables, and briefly reviews the most recent findings concerning its aetiology. (c) 2005 Elsevier Ltd. All rights reserved.
"The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cognition, communication, and behavior, by epilepsy and by secondary musculoskeletal problems . As one of the most common causes of physical disability in childhood, CP has an approximate prevalence of 1.5–3.6 per 1,000 individuals  . Despite extensive treatment, neurological impairments still eventually lead CP patients to lifelong disability . "
[Show abstract][Hide abstract] ABSTRACT: This retrospective study aimed to assess the safety of patients with severe cerebral palsy (CP), who received allogeneic umbilical cord blood stem cells (UCBSCs) treatment from August 2009 to December 2012 in Guangdong Provincial Hospital of Chinese Medicine. A total of 47 patients with average age of
years were evaluated in this study. There was no significant association with allogeneic UCBSCs treatments found in the data of the laboratory index . No casualties occurred. Some adverse events during treatments were found in 26 (55.3%) patients, including fever (42.6%) and vomiting (21.2%). Intrathecal infusion and the ages at the initiation of treatment (≤10 years old) were risk factors for the occurrence of adverse events by logistic regression analysis. However, all adverse events disappeared after symptomatic treatment. No treatment related serious adverse events were found in follow-up visits within 6 months. In conclusion, allogeneic UCBSCs treatment was relatively safe for severe CP patients.
Stem cell International 05/2015; 2015(2). DOI:10.1155/2015/325652 · 2.81 Impact Factor
"The prevalence of CP worldwide is estimated at between 2 and 2.5 cases per 1,000 births, and although the above definition emphasizes the motor nature of the disorder, it also recognizes that in most cases the problems are accompanied by changes in other areas and may be more intense or problematic depending on the person or their developmental stage (Blair 2010; Bottcher 2010; Odding et al. 2006). The first critical situation encountered by parents of children with CP is usually linked to the often complex process of confirming and disclosing the diagnosis (Baird et al. 2000). "
[Show abstract][Hide abstract] ABSTRACT: The implications of caring for a child with cerebral palsy (CP) are considerable, and parents have to cope with many changing demands related to the specific needs of their child. A new research field, devoted to the consequences of these caring tasks, has recently emerged. However, an overall vision is lacking, one that would enable us to understand how research is evolving and the relevant data that should be taken into account when planning interventions with these families. In this paper, we review the literature on the effects of caregiving on parents of children with CP, and summarize the factors related to these effects. A systematic search of online databases was performed and further studies were identified based on the reference lists of selected articles. Forty six articles that met the inclusion criteria were analysed. The review shows that caregivers of children with CP tend to have high levels of stress and depression and lower quality of life than parents of healthy children. We identify child behaviour and cognitive problems, low caregiver self-efficacy and low social support as factors that are consistently related with higher levels of stress and depression. The implications of these findings are discussed, especially those related to interventions that should be addressed to the family as a whole and which should aim to enhance parents’ competence and resources to better cope with the demands of the caring task.
Journal of Developmental and Physical Disabilities 10/2013; 25(5). DOI:10.1007/s10882-013-9332-6 · 1.56 Impact Factor
"Cerebral Palsy (CP) affects at least 2 in 1,000 children born in Western countries  and this number might increase as perinatal deaths and intrapartum injuries have been decreasing, leading to growth in the survival rate of premature babies , . CP significantly impacts motor performance, leading to deficits in muscle force generation and increases in muscle stiffness so that gait is marked by slow speed and disturbed motor control . "
[Show abstract][Hide abstract] ABSTRACT: We are designing a pediatric exoskeletal ankle robot (pediatric Anklebot) to promote gait habilitation in children with Cerebral Palsy (CP). Few studies have evaluated how much or whether the unilateral loading of a wearable exoskeleton may have the unwanted effect of altering significantly the gait. The purpose of this study was to evaluate whether adding masses up to 2.5 kg, the estimated overall added mass of the mentioned device, at the knee level alters the gait kinematics. Ten healthy children and eight children with CP, with light or mild gait impairment, walked wearing a knee brace with several masses. Gait parameters and lower-limb joint kinematics were analyzed with an optoelectronic system under six conditions: without brace (natural gait) and with masses placed at the knee level (0.5, 1.0, 1.5, 2.0, 2.5 kg). T-tests and repeated measures ANOVA tests were conducted in order to find noteworthy differences among the trial conditions and between loaded and unloaded legs. No statistically significant differences in gait parameters for both healthy children and children with CP were observed in the five "with added mass" conditions. We found significant differences among "natural gait" and "with added masses" conditions in knee flexion and hip extension angles for healthy children and in knee flexion angle for children with CP. This result can be interpreted as an effect of the mechanical constraint induced by the knee brace rather than the effect associated with load increase. The study demonstrates that the mechanical constraint induced by the brace has a measurable effect on the gait of healthy children and children with CP and that the added mass up to 2.5 kg does not alter the lower limb kinematics. This suggests that wearable devices weighing 25 N or less will not noticeably modify the gait patterns of the population examined here.
PLoS ONE 09/2013; 8(9):e73139. DOI:10.1371/journal.pone.0073139 · 3.23 Impact Factor
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