Social relationships, sleep quality, and interleukin-6 in aging women.

Robert Wood Johnson Health & Society Scholars Program, Department of Population Health Sciences, University of Wisconsin, Madison, WI 53726, USA.
Proceedings of the National Academy of Sciences (Impact Factor: 9.81). 01/2006; 102(51):18757-62. DOI: 10.1073/pnas.0509281102
Source: PubMed

ABSTRACT This study examined the interplay of social engagement, sleep quality, and plasma levels of interleukin-6 (IL-6) in a sample of aging women (n = 74, aged 61-90, M age = 73.4). Social engagement was assessed by questionnaire, sleep was assessed by using the NightCap in-home sleep monitoring system and the Pittsburgh Sleep Quality Index, and blood samples were obtained for analysis of plasma levels of IL-6. Regarding subjective assessment, poorer sleep (higher scores on the Pittsburgh Sleep Quality Index) was associated with lower positive social relations scores. Multivariate regression analyses showed that lower levels of plasma IL-6 were predicted by greater sleep efficiency (P < 0.001), measured objectively and by more positive social relations (P < 0.05). A significant interaction showed that women with the highest IL-6 levels were those with both poor sleep efficiency and poor social relations (P < 0.05). However, those with low sleep efficiency but compensating good relationships as well as women with poor relationships but compensating high sleep efficiency had IL-6 levels comparable to those with the protective influences of both good social ties and good sleep.

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    • "For this latter reason, future research is advised to treat many AL antecedents not only as covariates but also perhaps as mediators and/or moderators. For example, alcohol desensitization in rodents [17] interacts with sleep restriction, and poor social relationships in older women [18] interact with sleep quality to recalibrate AL biomarkers such as adenosine and interleukin-6. "
    Sleep Medicine 11/2014; 16(1). DOI:10.1016/j.sleep.2014.07.029 · 3.10 Impact Factor
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    • "Studies have also found a positive association between social support and healthy immune function. More specifically social support has been positively associated with immunoglobulin production (antibody titers) in response to certain vaccines (Glaser et al., 1992), while other studies have found a negative association with systemic inflammatory markers, such as interleukin 6 (IL-6; Friedman et al., 2005; Lutgendorf et al., 2000). Higher social support has been found to attenuate the relationship between depression and mortality related to cardiac events (Frasure-Smith et al., 2000). "
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    ABSTRACT: Psychosocial factors such as social support and depression have long been associated with health outcomes. Elevated depressive symptoms are usually associated with worse health outcomes, whereas social support has been related to improvements in health. Nitric oxide levels are an important marker of both cardiovascular health and immune function. Research suggests that exhaled nitric oxide is affected by stress, negative affect, and depression; however, the effect of social support has not been previously explored. Thus, we sought to examine the association of social support, negative affect, and depression with exhaled nitric oxide in a group of 35 healthy individuals (10 males and 25 females) with a mean age of 20.5years across five weekly assessments. Results showed that changes in social support within individuals were positively associated with levels of exhaled nitric oxide independent of other psychosocial factors. Further exploration of the health implications of this positive relationship between airway nitric oxide and social support is necessary.
    International journal of psychophysiology: official journal of the International Organization of Psychophysiology 05/2014; DOI:10.1016/j.ijpsycho.2014.05.011 · 2.65 Impact Factor
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    • "Poor sleep quality has been significantly associated with lower levels of social support, higher levels of interpersonal conflict, and higher levels of loneliness (Cacioppo et al. 2002; Fortunato and Harsh 2006; Segrin and Domschke 2011). In general, individuals who report more negative social ties tend to report more sleep problems (Aanes et al. 2011; Ailshire and Burgard 2012; Friedman et al. 2005). For example, Howell et al. (2008) found that higher social well being (e.g., social integration) was significantly correlated with better overall sleep quality among university students. "
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    ABSTRACT: Despite the growing body of research linking sleep problems and social ties, research investigating the direction of effects between these two constructs is lacking. Furthermore, there remains a dearth of research examining the mechanisms that may explain the association between sleep problems and social ties within a longitudinal design. The present 3-year longitudinal study addressed two research questions: (1) Is there a bidirectional association between sleep problems and social ties at university? and (2) Does emotion regulation mediate the association between sleep problems and social ties at university? Participants (N = 942, 71.5 % female; M = 19.01 years at Time 1, SD = 0.90) were university students who completed annual assessments of sleep problems, social ties, and emotion regulation, for three consecutive years. Results of path analysis indicated that the bidirectional association between sleep problems and social ties was statistically significant (controlling for demographics, sleep-wake inconsistency, sleep duration, and alcohol). Analyses of indirect effects indicated that emotion regulation mediated this link, such that better sleep quality (i.e., less sleep problems) led to more effective emotion regulation, which, subsequently, led to more positive social ties. In addition, more positive social ties led to more effective emotion regulation, which, in turn, led to less sleep problems. The findings highlight the critical role that emotional regulation plays in the link between sleep problems and social ties, and emphasize the need for students as well as university administration to pay close attention to both the sleep and social environment of university students.
    Journal of Youth and Adolescence 02/2014; 44(2). DOI:10.1007/s10964-014-0107-x · 2.72 Impact Factor
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