Hospital admission with neonatal sepsis and development of atopic disease: Is there a link?
University Children's Hospital, Freiburg, Germany.Pediatric Allergy and Immunology (Impact Factor: 3.4). 12/2005; 16(8):630-6. DOI: 10.1111/j.1399-3038.2005.00322.x
The role of suspected or confirmed neonatal sepsis in modifying the risk of atopic disease during childhood was assessed. Children with early-onset neonatal sepsis were identified from a cohort of neonates, hospitalized between 1990 and 1995. Of 196 individuals, 140 were recruited (71.4%). Pre- and postnatal history was ascertained from neonatal medical records. Based on clinical symptoms and a positive blood culture or at least three of initially defined laboratory or bacteriological criteria, they were stratified in either confirmed neonatal sepsis (CS) or suspected sepsis (SS) group. A control group (C) comprised children who were never hospitalized during infancy (n = 696). Primary end-point was the development of atopic dermatitis, bronchial asthma or allergic rhinitis during childhood (mean age 8.4 yr, range 5.7-12.4). CS and SS children had a higher prevalence of atopic dermatitis (CS 15.7%, SS 21.4%) compared with controls (C 5.2%, p < 0.001). Similarly, children with SS (7.1%), but not with CS (4.3%) had significantly more often a doctor's diagnosis of bronchial asthma compared to controls (1.9%, p = 0.02). No difference in the prevalence of allergic rhinitis was observed (CS 4.3%, SS 10%, C 8.3%). After adjusting for parental history of atopic disease and demographic factors, no significant difference for the risk to develop atopic dermatitis, asthma or allergic rhinitis among the groups was calculated in children with normal birth weight (>2500 g). Our data failed to show a possible link between hospital admission with SS and development of atopic disease.
Article: Infezioni e dermatite atopica[Show abstract] [Hide abstract]
ABSTRACT: Pur essendo geneticamente determinata, la dermatite atopica (DA) è condizionata nel suo decorso clinico e, almeno in alcuni casi, nel suo sviluppo da agenti esogeni: tra questi fattori ambientali,un ruolo importante giocano i fattori biotici,batterici, in particolare lo stafilococco aureo (SA), virali e micotici.
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ABSTRACT: The role of infections on the development of atopy is still widely debated. We aimed to evaluate the effects of neonatal severe sepsis and consequent antibiotic treatment on the development of atopy and allergic diseases. A retrospective enrollment at school age of children with a clear history of neonatal sepsis (NS) was performed from registers of neonatal intensive care units. A normal control was assigned to each patient with sepsis. Thirty six cases with sepsis (18 males, 18 females) and 36 controls (21 males, 15 females) were selected (8.5+/-3.6 yrs). Physical examination and lung function evaluation were performed. Atopic status was verified by blood eosinophil count, total IgE serum level and skin prick tests (SPT). SPT positivity for at least one allergen was present in 30% of subjects in both groups. No difference for all investigated parameters between groups and no influence by other factors such as familiarity or gender was observed. No correlation was associated to NS history. Neonatal sepsis, even if clinically severe and dramatic, could represent an event too limited and really precocious in life to influence the development of immune response. Furthermore, other factors, besides infections, may influence the atopic future of newborns.Allergologia et Immunopathologia 10/2009; 37(6):281-4. DOI:10.1016/j.aller.2009.05.007 · 1.74 Impact Factor
- Allergologia et Immunopathologia 11/2009; 37(6):279-80. DOI:10.1016/j.aller.2009.10.002 · 1.74 Impact Factor
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