Dysfunction of lamin A triggers a DNA damage response and cellular senescence.

Department of Biochemistry & Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alta., Canada T2N 4N1.
DNA Repair (Impact Factor: 3.36). 03/2006; 5(2):286-9. DOI: 10.1016/j.dnarep.2005.10.007
Source: PubMed

ABSTRACT In higher eukaryotes, the nuclear lamins play an important role in maintaining the integrity of the nuclear envelope and the nucleus itself. Two recent papers show that a mutation that affects the processing of one of the nuclear lamins, lamin A, results in increased sensitivity to DNA damaging agents, an elevated DNA damage response, and a senescent phenotype. These studies underscore the role of the nuclear envelope in maintaining genomic stability and the interplay between nuclear architecture and the DNA damage response.

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