Obesity and migraine - A population study

Albert Einstein College of Medicine, New York, New York, United States
Neurology (Impact Factor: 8.3). 02/2006; 66(4):545-50. DOI: 10.1212/01.wnl.0000197218.05284.82
Source: PubMed

ABSTRACT To assess the influence of body mass index (BMI) on the prevalence, attack frequency, and clinical features of migraine.
In a population-based telephone interview study, the authors gathered information on headache, height, and weight. The 30,215 participants were divided into five categories, based on BMI: 1, underweight (< 18.5), normal weight (18.5 to 24.9), overweight (25 to 29.9), obese (30 to 24.9), and morbidly obese (> or = 35). Migraine prevalence and modeled headache features were assessed as a function of BMI, adjusting by covariates (age, sex, marital status, income, medical treatment, depression).
Subjects were predominantly female (65% female) and in middle life (mean age 38.4). BMI group was not associated with the prevalence of migraine, but was associated with the frequency of headache attacks. In the normal weight group, 4.4% had 10 to 15 headache days per month, increasing to 5.8% of the overweight (odds ratio [OR] = 1.3), 13.6% of the obese (OR = 2.9), and 20.7% of the morbidly obese (OR = 5.7). The proportion of subjects with severe headache pain increased with BMI, doubling in the morbidly obese relative to the normally weighted (OR = 1.9). Similar significant associations were demonstrated with BMI category for disability, photophobia, and phonophobia.
Though migraine prevalence is not associated with body mass index, attack frequency, severity, and clinical features of migraine increase with body mass index group.

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Available from: Marcelo Bigal, May 13, 2014
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    • "Bigal et al. [9] "
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    ABSTRACT: The aim of this study is to determine a possible relationship between prevalence, frequency, and severity of migraine and obesity. All pertinent data from the literature have been critically examined and reviewed in order to assess the possible relationship between obesity and migraine, in particular migraine frequency and disability in children, as well as in adult population studies. Prevalence, frequency, and severity of migraine appear to increase in relation to the body mass index, although this evidence is not supported by all the studies examined. Data from literature suggest that obesity can be linked with migraine prevalence, frequency, and disability both in pediatric and adult subjects. These data have important clinical implications and suggest that clinicians should have a special interest for weight reduction of obese children suffering from migraine, prescribing and supporting intensive lifestyle modifications (dietary, physical activities, and behavioral) for the patient and the entire family.
    04/2014; 2014:420858. DOI:10.1155/2014/420858
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    • "Association between obesity and primary headaches was firstly described by Scher et al. [11]. Obesity is a proinflammatory condition with vascular hyperactivity where concentration of inflammatory mediators and plasma CGRP (calcitonin gene-related peptide) increases, while that of adiponectin decreases [3] [4]. These characteristics increase frequency of migraine attacks and induce central sensitization leading to the development of chronic migraine. "
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    ABSTRACT: Background. Our aim was to investigate the association between migraine, tension type headache, and metabolic syndrome. Methods. Presence of tension type headache and migraine was investigated in 120 patients diagnosed as metabolic syndrome. The severity of the headache was recorded according to the visual analog scale. Results. Mean age of the patients was 54.41 ± 11.60 years (range, 29-84 yrs). Diagnoses of tension type headache and migraine without aura were made for 39 (32.5%) and 18 (15%) patients, respectively. Mean age of migraine patients was significantly lower relative to the patients with tension type headache and no headache. Incidence of hypertriglyceridemia was significantly higher in migraine patients when compared with cases tension type headache and without headache. In the tension type headache group, requirement for analgesics decreased as HDL cholesterol levels increased, while need for analgesic drugs increased in line with higher diastolic blood pressures. In the migraine group duration of headache was found to be prolonged with decreasing HDL cholesterol levels. Conclusion. In patients presenting with headache, its association with metabolic syndrome should be considered, and the patients should be especially observed with respect to response to analgesic and the presence of hypertension and hyperlipidemia.
    04/2013; 2013(19):147065. DOI:10.1155/2013/147065
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    • "Given the recently characterized metabolic activity of adipose tissue (Bigal et al., 2007a), the interaction between obesity and migraine is particularly complex and has been the subject of multiple large and conflicting studies. Population-based studies suggest that obesity is not associated with migraine prevalence (Bigal et al., 2006b) but may be a risk factor for the transformation of episodic migraine to chronic migraine (Scher et al., 2003; Bigal and Lipton, 2006). Bigal et al. studied 30,215 subjects, 3,791 of whom reported migraine symptoms. "
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    ABSTRACT: Migraine and metabolic syndrome are highly prevalent and costly conditions. The two conditions coexist, but it is unclear what relationship may exist between the two processes. Metabolic syndrome involves a number of findings, including insulin resistance, systemic hypertension, obesity, a proinflammatory state, and a prothrombotic state. Only one study addresses migraine in metabolic syndrome, finding significant differences in the presentation of metabolic syndrome in migraineurs. However, controversy exists regarding the contribution of each individual risk factor to migraine pathogenesis and prevalence. It is unclear what treatment implications, if any, exist as a result of the concomitant diagnosis of migraine and metabolic syndrome. The cornerstone of migraine and metabolic syndrome treatments is prevention, relying heavily on diet modification, sleep hygiene, medication use, and exercise.
    Frontiers in Neurology 11/2012; 3(article 161):161. DOI:10.3389/fneur.2012.00161
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