Cellular angiofibroma of the vulva: case report with clinicopathological and immunohistochemistry study.

Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
Sao Paulo Medical Journal (Impact Factor: 0.7). 09/2005; 123(5):250-2. DOI: 10.1590/S1516-31802005000500010
Source: PubMed

ABSTRACT CONTEXT: Cellular angiofibroma of the vulva is a rare tumor that was first described in 1997. It occurs in middle-aged women (average age: 47 years), has small size (< 3 cm) and well-circumscribed margins. CASE REPORT: We describe a case in a 51-year-old woman whose preoperative diagnosis was confounded with Bartholin's glandular cyst. The neoplasia was well delimited and made up of three characteristic components: fusiform cells forming small fascicles, numerous blood vessels and adipose tissue interspersed between the fusiform cells. The stroma cells were positive for vimentin and negative for CD34, protein S-100, actin and desmin. The differential diagnoses for this tumor include aggressive angiomyxoma, angiomyofibroblastoma, lipoma of fusiform cells, solitary fibrous tumor, perineurioma and leiomyoma.

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