Cellular angiofibroma of the vulva: Case report with clinicopathological and immunohistochemistry study

Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
Sao Paulo Medical Journal (Impact Factor: 0.72). 09/2005; 123(5):250-2. DOI: 10.1590/S1516-31802005000500010
Source: PubMed


CONTEXT: Cellular angiofibroma of the vulva is a rare tumor that was first described in 1997. It occurs in middle-aged women (average age: 47 years), has small size (< 3 cm) and well-circumscribed margins. CASE REPORT: We describe a case in a 51-year-old woman whose preoperative diagnosis was confounded with Bartholin's glandular cyst. The neoplasia was well delimited and made up of three characteristic components: fusiform cells forming small fascicles, numerous blood vessels and adipose tissue interspersed between the fusiform cells. The stroma cells were positive for vimentin and negative for CD34, protein S-100, actin and desmin. The differential diagnoses for this tumor include aggressive angiomyxoma, angiomyofibroblastoma, lipoma of fusiform cells, solitary fibrous tumor, perineurioma and leiomyoma.

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    • "Previous literature has described instances of pathology occurring concurrently with Bartholin's abscess or cyst. Literature describes a case of cellular angiofibroma for which the preoperative diagnosis was Bartholin's glandular cyst [3]. Another case report described a vulvar mass that was preoperatively diagnosed as a Bartholin's duct cyst but found to be leiomyosarcoma, a rare gynecologic malignancy [4]. "
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    ABSTRACT: Hidradenoma papilliferum is an uncommon, benign, cystic, papillary tumor that occurs almost exclusively in the female anogenital region. Bartholin's abscess is also an anogenital cystic lesion caused by obstruction of Bartholin's duct with an overlying infection. Concomitant presentation of Bartholin's abscess and Hidradenoma papilliferum is unique. A 43-year-old African American woman presented with a painful cystic mass on the left labia majora. A preoperative diagnosis of Bartholin's abscess was made. During excision and draining, an additional tan-brown dermal nodule was removed which demonstrated histological features of Hidradenoma papilliferum. We present what we believe to be the first case of Bartholin's abscess arising in hidradenoma papilliferum and its clinical significance.
    Cases Journal 02/2008; 1(1):282. DOI:10.1186/1757-1626-1-282
  • Revista brasileira de malariologia e doenças tropicais. Publicações avulsas 02/1982; 34:1-31.
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    ABSTRACT: The vulvar cellular angiofibroma is a rare mesenchymal tumor. It can be located in many places, but it is more frequent in the vulvar area. It is characterized for being of superficial and slow-growth and for having low propensity of local recurrence. It was described in 1997 by Nucci and it had been reported 51 cases worldwide, from which 18 had vulvar location. This is the first case in Mexico City. It was found in a 36 years-old woman. The specimen was processed by structural and immunohistochemical analysis. Misdiagnosis is common and it can be confounded with spindle cell lipoma, hydrocele of the canal of Nuck, fibromas, angiomyofibroblastoma and many other mesenchymal tumors. It should be distinguished from the aggresive angiomixoma. To improve the clinical diagnosis and treatment, it is very important to have in mind this relatively new entity.
    Ginecología y obstetricia de México 10/2006; 74(9):499-502.
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