Lymphocyte calcium signaling from membrane to nucleus.

Program in Immunology, Stanford University, Stanford, California 94305, USA.
Nature Immunology (Impact Factor: 24.97). 02/2006; 7(1):25-32. DOI: 10.1038/ni1295
Source: PubMed

ABSTRACT Ca(2+) signals control a variety of lymphocyte responses, ranging from short-term cytoskeletal modifications to long-term changes in gene expression. The identification of molecules and channels that modulate Ca(2+) entry into T and B lymphocytes has both provided details of the molecular events leading to immune responses and raised controversy. Here we review studies of the pathways that allow Ca(2+) entry, the function of Ca(2+) in the regulation of cell polarity and motility and the principles by which Ca(2+)-dependent transcription regulates lymphocyte function.

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