Article

Gap junctions in skeletal development and function

University of Maryland School of Medicine, Department of Orthopaedics, Baltimore, MD 21201, USA.
Biochimica et Biophysica Acta (Impact Factor: 4.66). 01/2006; 1719(1-2):69-81. DOI: 10.1016/j.bbamem.2005.10.012
Source: PubMed

ABSTRACT Gap junctions play a critical role in the coordinated function and activity of nearly all of the skeletal cells. This is not surprising, given the elaborate orchestration of skeletal patterning, bone modeling and subsequent remodeling, as well as the mechanical stresses, strains and adaptive responses that the skeleton must accommodate. Much remains to be learned regarding the role of gap junctions and hemichannels in these processes. A common theme is that without connexins none of the cells of bone function properly. Thus, connexins play an important role in skeletal form and function.

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Available from: Roberto Civitelli, Jan 15, 2014
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