A prospective randomized controlled trial to determine if cryotherapy can reduce the pain of patients with minor form of recurrent aphthous stomatitis.
ABSTRACT Tissue cooling has long been used in the management of both acute and chronic pain.
To determine whether the application of cryotherapy can reduce the pain of patients with minor form of recurrent aphthous stomatitis.
Twenty adult patients who had 2 discrete aphthous stomatitides in the labial mucosa at the same time were included in this prospective, randomized, and placebo-controlled study. One of the 2 aphthous stomatitides was treated with cryotherapy, the other serving as a control. The pain of aphthous stomatitis was scored by the patient on a 6-point scale (from 0 to 5). The size of the aphthous stomatitis was also measured.
At any interval, no statistical difference was found between the cryotherapy-treated aphthous stomatitis and the control in the change in the value of pain severity, nor was any statistical difference found in the change in the size of the aphthous stomatitis. However, a trend toward less pain in the aphthous stomatitis receiving cryotherapy was noted.
These results suggest that application of cryotherapy on minor form of recurrent oral aphthous stomatitis has no beneficial analgesic effect compared to placebo.
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ABSTRACT: Recurrent aphthous ulcers (RAU) are the most common oral ulcerative disease, affecting 10% to 20% of the population. There are 3 clinical subtypes-minor, major, and herpetiform. Minor aphthous ulcers are the most common subtype, representing 80% to 90% of all recurrent aphthous ulcers. Clinically, RAU present as extremely painful, shallow ulcerations with an erythematous halo on unattached oral mucosa. The primary differential diagnosis is oral herpes simplex. The etiology of RAU is unknown. Topical corticosteroids are the mainstay of therapy.American Journal of Otolaryngology 01/2000; 21(6):389-93. · 1.23 Impact Factor
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ABSTRACT: This article describes a simple and effective cryosurgical treatment for 92 patients who had 102 benign oral lesions. The procedure was performed by direct application of liquid nitrogen to the lesion using a cotton swab on an outpatient basis. This treatment required no sophisticated equipment and gave very satisfactory results. There was no intra- or postoperative bleeding, no surgical defects, minimal scarring, and no infection following treatment. The results demonstrate that this is an atraumatic form of therapy in comparison to conventional surgery.International Journal of Oral and Maxillofacial Surgery 07/2000; 29(3):212-6. · 1.52 Impact Factor
Article: Recurrent aphthous stomatitis.[show abstract] [hide abstract]
ABSTRACT: Recurrent aphthous stomatitis is the most common oral mucosal disease in North America but it is commonly misdiagnosed and poorly understood. Pediatricians, internists, otolaryngologists, oral surgeons, and dentists may all be expected to treat this illness but little formal training in oral medicine may be offered to many of these health care professionals. This article reviews current evidence regarding etiology, pathogenesis, natural history, and treatment of this disorder.The Journal of the Louisiana State Medical Society: official organ of the Louisiana State Medical Society 02/2000; 152(1):10-4.