A prospective randomized controlled trial to determine if cryotherapy can reduce the pain of patient with minor form of recurrent aphthous stomatitis
Tissue cooling has long been used in the management of both acute and chronic pain.
To determine whether the application of cryotherapy can reduce the pain of patients with minor form of recurrent aphthous stomatitis.
Twenty adult patients who had 2 discrete aphthous stomatitides in the labial mucosa at the same time were included in this prospective, randomized, and placebo-controlled study. One of the 2 aphthous stomatitides was treated with cryotherapy, the other serving as a control. The pain of aphthous stomatitis was scored by the patient on a 6-point scale (from 0 to 5). The size of the aphthous stomatitis was also measured.
At any interval, no statistical difference was found between the cryotherapy-treated aphthous stomatitis and the control in the change in the value of pain severity, nor was any statistical difference found in the change in the size of the aphthous stomatitis. However, a trend toward less pain in the aphthous stomatitis receiving cryotherapy was noted.
These results suggest that application of cryotherapy on minor form of recurrent oral aphthous stomatitis has no beneficial analgesic effect compared to placebo.
Available from: Nasrin Zand
- "The main problem with aphthous ulcers is their pain which may be so severe. Many different therapeutic agents, including topical corticosteroids, mouth rinses, antibiotics, local anesthetic gels or pastilles, and treatment modalities, such as silver nitrate cautery and cryotherapy, have been tried for pain control in miRAS patients (Alidaee, Taheri et al. 2005; Arikan, Birol et al. 2006). Fig. 2. Minor aphthous ulcer Fig. 3. Major aphthous ulcer "
CO2 Laser - Optimisation and Application, 03/2012; , ISBN: 978-953-51-0351-6
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ABSTRACT: A new algorithm based on semidefinite programming is presented for estimation of distributed source fields measured through a sensor array. The problem can be viewed as a subclass of inverse problems, which have been extensively investigated in the literature. Our approach is based on the so called information based complexity (IBC) paradigm, which formalizes the notion of seeking the set of all solutions that are consistent with the observed data. We formulate our problem as a question of estimating the source up to a prespecified resolution (average source field in a neighborhood) from the observed data with optimal accuracy. We show that this problem is convex and can be reformulated as a semidefinite program.
Signals, Systems and Computers, 2003. Conference Record of the Thirty-Seventh Asilomar Conference on; 12/2003
Available from: eprints.ru.ac.za
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