Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by Chlamydia trachomatis serotypes L1, L2, and L3. It is endemic in tropical areas, while seldom in industrialised countries. Since 2002, an outbreak of rectal LGV has been observed among men having sex with men, in Netherlands, France, and other countries of Western Europe. After an incubation period of 2 days to 2 months, LGV develops in three stages: ulcerated papule; inflammatory satellite lymph node and/or proctitis; chronic inflammatory complications (fistulas and sclerosis). Chlamydia trachomatis infection is confirmed by PCR and serovars is identified by RFLP of omp1 gene amplified by PCR. Recommended first line treatment is doxycycline for at least 21 days.
"Serovars L1 to L3 can infect both urogenital and rectal tissues, causing lymphogranuloma venereum (LGV) (Bauwens et al., 2002). It has been recently reported that the LGV serovars can cause occasional outbreaks of LGV among men having sex with men in industrialized nations (Farhi & Dupin, 2005). Chlamydia pneumoniae is a major cause of various respiratory illnesses, and respiratory infection with C. pneumoniae is also linked to cardiovascular pathologies such as atherosclerosis (Campbell & Kuo, 2002, 2004). "
[Show abstract][Hide abstract] ABSTRACT: Chlamydia trachomatis is an obligate intracellular bacterium and acquires both building blocks and energy from host cells for growth. The fatty acid-binding protein (FABP) plays an important role in uptake of long-chain fatty acids (LCFA) and energy metabolism by eukaryotic cells. The roles of FABP and LCFA in chlamydial infection were evaluated. Infection of liver cells with chlamydial organisms promoted fatty acid uptake by the infected cells, suggesting that LCFA may benefit chlamydial growth. Introduction of FABP into the liver cells not only enhanced fatty acid uptake, but also increased chlamydial intravacuolar replication and maturation. The FABP-enhanced chlamydial intracellular growth was dependent on the host cell uptake of fatty acids. These results have demonstrated that C. trachomatis can productively infect liver cells and utilize FABP-transported LCFA for its own biosynthesis.
[Show abstract][Hide abstract] ABSTRACT: This review deals with the most recent reports on male homosexuality (H) and lesbianism (L). The reviewer checked the most recent 1000 articles in the Internet’s Medline to report the major new findings in H and L. First discussed is the presumed etiology or cause, including the “maternal immunization hypothesis” and the evidence for both genetic and environmental factors. Next the prevalence in various countries is reported. The related diseases include HIV+, syphilis and other venereal diseases. Factors like drug involvement, unprotected anal sex, casual partners are included, as is suicidal ideation, violence, child molestation and changes in sexual orientation over time. The goal of this review is to make available to all readers the most recent reports on H and L so that pre-existing problems and any new disorders that have arisen can be better understood and that attempts at their solution can be pursued.
Sexuality and Disability 11/2006; 24(4):195-205. DOI:10.1007/s11195-006-9025-5 · 0.72 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Anorectal Lymphogranuloma Venereum (AR-LGV) has recently been recognized as an emerging problem among HIV-infected men who have sex with men (MSM). AR-LGV may resemble other conditions such as Crohn's disease, resulting in misdiagnosis and the potential for the development of disabling and irreversible long-term complications. Prompt, appropriate antibiotic therapy is essential. We review the epidemiology, pathology, clinical presentation, diagnosis, treatment and public health concerns of AR-LGV.
HIV and AIDS Review 01/2007; 6(1):12-19. DOI:10.1016/S1730-1270(10)60036-7
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