Article

Celiac disease in Tunisia: serological screening in healthy blood donors.

Faculty of Pharmacy, Monastir, Tunisia.
Pathologie Biologie (impact factor: 1.53). 03/2006; 54(1):10-3. DOI:10.1016/j.patbio.2005.02.005 pp.10-3
Source: PubMed

ABSTRACT Recent epidemiological studies in Europe and in USA using antigliadin antibodies and antiendomysium antibodies for initial screening have shown that the overall prevalence of celiac disease (CD) is about 1:200 (0.5%).
To screen for CD in healthy blood donors in Tunisia.
Sera from 2500 healthy blood donors (median age: 21 years, 70% men and 30% women) were screened for IgG-antigliadin antibodies and IgA-antigliadin antibodies with an enzyme-linked immunosorbent assay. All sera with positive antigliadin antibodies were tested for antiendomysium antibodies using human umbilical cord cryosections as substrate.
Seven healthy blood donors (median age: 21 years; four men, three women) have antiendomysium antibodies. The prevalence of antiendomysium antibodies in healthy blood donors in Tunisia is 1:355 (0.28%).
On the basis of a high specificity of the antiendomysium antibodies, it is likely that the seven blood donors identified in this study have CD. These data suggest that CD is frequent in Tunisia.

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Keywords

2500 healthy blood donors
 
antiendomysium antibodies
 
antigliadin antibodies
 
celiac disease
 
enzyme-linked immunosorbent assay
 
Europe
 
healthy blood donors
 
human umbilical cord cryosections
 
IgA-antigliadin antibodies
 
IgG-antigliadin antibodies
 
initial screening
 
median age
 
positive antigliadin antibodies
 
prevalence
 
Recent epidemiological studies
 
sera
 
seven blood donors
 
USA
 
women