The role of vitamin D in cancer prevention.

Department of Family and Preventive Medicine, 0631C, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0631, USA.
American Journal of Public Health (Impact Factor: 4.23). 03/2006; 96(2):252-61. DOI: 10.2105/AJPH.2004.045260
Source: PubMed

ABSTRACT Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk. The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects.

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