Short-term intraocular pressure trends following intravitreal pegaptanib (Macugen) injection.

Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, USA.
American Journal of Ophthalmology (Impact Factor: 3.63). 02/2006; 141(1):200-1. DOI: 10.1016/j.ajo.2005.07.053
Source: PubMed

ABSTRACT To report the changes and trends in intraocular pressures (IOP) following intravitreal injection of Pegaptanib (Macugen) for the treatment of exudative age-related macular degeneration.
Retrospective chart review.
Review of 79 patients who underwent 122 consecutive Pegaptanib injections. Analysis of the short-term effect of Pegaptanib injections on IOP was performed.
Baseline mean IOP was 15.73 +/- 3.41 mm Hg (mean +/- standard deviation) with a range of 9 to 27 mm Hg. Postinjection mean IOP was 24.47 +/- 6.29 mm Hg with a range of 8 to 36 mm Hg. Mean IOP change from baseline to roughly 30 minutes after Pegaptanib injection was 8.74 +/- 7.23 mm Hg. At the 5- to 7-day follow-up visit, IOP had normalized.
Pegaptanib injection in this limited series seems to be safe from an IOP standpoint in the short-term. IOP monitoring postinjection may not be necessary.

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