Protracted remission of metastatic epithelioid angiosarcoma with weekly infusion of doxorubicin, paclitaxel, and cisplatin

Division of Cancer Medicine, MD Anderson Cancer Centre, Houston, TX 77230-1439, USA.
The Lancet Oncology (Impact Factor: 24.69). 02/2006; 7(1):92-3. DOI: 10.1016/S1470-2045(05)70542-8
Source: PubMed
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    • "Very few cases of angiosarcoma of the prostate or seminal vesicle have been reported in the literature (Table 1).4-14 For angiosarcomas of the seminal vesicle, presenting symptoms may include testicular discomfort and perineal pain which may radiate to the lower back.11,13,14 Prostatic angiosarcoma can present with symptoms similar to prostatic adenocarcinoma, including dysuria, hematuria, or pelvic pain.7 Biopsy is required for definitive diagnosis. "
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    ABSTRACT: Angiosarcoma of the seminal vesicle is an extremely rare malignancy, with few published case reports in the literature. We present a case of primary angiosarcoma of the seminal vesicle in a 45-year-old male who was treated with multimodality therapy, consisting of neoadjuvant chemotherapy and chemoradiation followed by surgical resection and intraoperative radiation therapy. He has been free of cancer recurrence for more than six years after completion of therapy. To our knowledge, this represents the longest reported survival of a patient with this rare tumor, and one of the few cases reported using a multimodality therapy approach.
    Rare tumors 01/2014; 6(1):5202. DOI:10.4081/rt.2014.5202
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    ABSTRACT: Among angiosarcomas, radiation-induced breast sarcomas (RIBS) represent a well-known entity generally characterized by a poor outcome, especially in patients with advanced disease. Despite the unfavorable prognosis, some chemotherapeutic agents have been used to treat these malignancies, occasionally with success. Treatments with demonstrated activity against sarcomas include ifosfamide-based regimens and, more recently, taxane derivatives. We report a case of a patient having a secondary breast angiosarcoma recurring early after surgery, who achieved complete remission following treatment with weekly paclitaxel. After 4 years of maintenance therapy, with an interval between consecutive administrations of no longer than 3 weeks, the patient is still in complete remission. A locoregional recurrence was documented twice during this period, the first as a consequence of a brief treatment interruption and the second because of a treatment delay. Nonetheless, in both instances a new complete remission was rapidly achieved with the resumption of the same treatment, without evidence of any significant adverse effects. We discuss the highly unusual behavior of this malignancy and the possible role of the two different mechanisms of action of paclitaxel-antiangiogenic versus cytotoxic-depending on the schedule of administration, with evidence of "false" drug-resistance.
    Tumori 95(6):828-31. · 1.27 Impact Factor
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    ABSTRACT: In manufacturing processes, there are many manipulative operations which deal with deformable objects. In this paper we analyse the dynamic motion analysis of deformable rodlike objects. First, a geometric representation to describe the shape of a rodlike object with dynamic deformation is introduced. The potential and kinetic energy of the object and the geometric constraints imposed on it are then formulated. The shape of the dynamically deforming object can be derived by minimizing the difference between the kinetic energy and potential energy under the geometric constraints. Next, a procedure to compute the deformed shape is developed by use of Euler's approach. Finally, some numerical examples are shown in order to demonstrate how the proposed approach computes the shapes of deformed rodlike objects
    Intelligent Robots and Systems, 1997. IROS '97., Proceedings of the 1997 IEEE/RSJ International Conference on; 10/1997
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