A 69-year-old woman with a vulvar lesion. Phyllodes tumor of the vulva.

Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA.
Archives of pathology & laboratory medicine (Impact Factor: 2.88). 02/2006; 130(1):e11-2. DOI: 10.1043/1543-2165(2006)130[e11:AYWWAV]2.0.CO;2
Source: PubMed
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    ABSTRACT: Mammary-type fibroepithelial neoplasms of the vulva are rare lesions of uncertain histogenesis. Origin from ectopic breast tissue and from anogenital glandular tissue that shares similar histologic homology with breast tissue has been postulated. We report the case of a 45-year-old woman who presented with a vulvar mass of several years duration. Excision of the lesion and subsequent histologic examination showed a mammary-type fibroadenoma with apocrine change. No ectopic breast tissue was identified outside the lesion. The theories of histogenesis of these neoplasms and additional cases of mammary-type lesions of the vulva reported in the medical literature are reviewed.
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    ABSTRACT: We describe a phyllodes tumor of borderline malignancy in the labium majus of a 49-year-old woman. The histogenetic origin of phyllodes tumors in the vulva is controversial. Strong immunoreactivity for NY-BR-1, a novel breast differentiation antigen, was demonstrated within the epithelial components of the phyllodes tumor. A similar expression pattern was observed in mammary-like glands of the vulva. These findings provide further evidence that phyllodes tumors of the vulva might derive from mammary-like glands in the labium majus or from ectopic breast tissue.
    Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 05/2007; 450(4):471-4. DOI:10.1007/s00428-007-0377-8 · 2.56 Impact Factor