European multi-centre study on coeliac disease and non-Hodgkin lymphoma.

Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands.
European Journal of Gastroenterology & Hepatology (Impact Factor: 2.15). 03/2006; 18(2):187-94. DOI: 10.1097/00042737-200602000-00012
Source: PubMed

ABSTRACT Coeliac disease (CD) is associated with an increased risk of non-Hodgkin lymphoma (NHL), but there is little information about whether this is true for clinically silent CD.
To investigate the frequency of CD in two European populations; one with NHL and another derived from the general population.
A prospective, multi-centre, case-control study in 10 European countries was conducted between May 1998 and April 2001. A total of 1446 consecutive patients with newly diagnosed NHL aged over 18 years was collected. The control group consisted of a population of 9676 individuals who were screened for CD. The number of patients with a previous diagnosis of CD and those with silent CD detected by screening were determined in the two groups.
The patients with CD had a significantly increased risk of developing NHL [odds ratio (OR) 2.6, 95% confidence interval (CI) 1.4-4.9]. This risk was only present in patients with CD diagnosed clinically before the study (OR 3.3, 95% CI 1.4-7.9), but not in those with silent CD detected by screening (OR 1.3, 95% CI 0.6-2.7).
Patients with CD have an increased risk of developing NHL, although this is lower than previously thought. Clinically silent CD is rare in patients with NHL.

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