Article

LAMARC 2.0: maximum likelihood and Bayesian estimation of population parameters.

Department of Genome Sciences Box 357730 University of Washington Seattle, 98195-7730, USA.
Bioinformatics (Impact Factor: 4.62). 04/2006; 22(6):768-70. DOI: 10.1093/bioinformatics/btk051
Source: PubMed

ABSTRACT We present a Markov chain Monte Carlo coalescent genealogy sampler, LAMARC 2.0, which estimates population genetic parameters from genetic data. LAMARC can co-estimate subpopulation Theta = 4N(e)mu, immigration rates, subpopulation exponential growth rates and overall recombination rate, or a user-specified subset of these parameters. It can perform either maximum-likelihood or Bayesian analysis, and accomodates nucleotide sequence, SNP, microsatellite or elecrophoretic data, with resolved or unresolved haplotypes. It is available as portable source code and executables for all three major platforms. AVAILABILITY: LAMARC 2.0 is freely available at http://evolution.gs.washington.edu/lamarc

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