Article

[Effects of electroacupuncture treatment on nitrergic neurotransmitter in bladder neck and detrusor of rats with unstable bladder].

Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Journal of Chinese Integrative Medicine 02/2006; 4(1):73-5.
Source: PubMed

ABSTRACT To observe the effects of electroacupuncture treatment on nitrergic neurotransmitter in bladder neck and detrusor of rats with unstable bladder.
Rat models of unstable bladder were established by operation to induce urethral obstruction. Electroacupuncture treatment was given by acupuncturing Huiyang and Zhonglushu points for a week. Then the neuronal nitric oxide synthase (nNOS)-, endothelial nitric oxide synthase (eNOS)- and inducible nitric oxide synthase (iNOS)-positive cells in bladder neck and detrusor of the rats were observed.
The nitrergic neurotransmitter in bladder neck and detrusor were obviously decreased in rats with unstable bladder. The electroacupuncture treatment could significantly increase the contains of NOS in bladder tissue.
To promote the synthesis and secretion of nitrergic neurotransmitter in bladder tissue may be one of the mechanisms of acupuncture in adjusting bladder function.

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Keywords

acupuncturing Huiyang
 
bladder function
 
bladder neck
 
bladder tissue
 
detrusor
 
Electroacupuncture treatment
 
endothelial nitric oxide synthase
 
eNOS)-
 
induce urethral obstruction
 
inducible nitric oxide synthase
 
iNOS)-positive cells
 
neuronal nitric oxide synthase
 
nitrergic neurotransmitter
 
nNOS)-
 
Rat models
 
rats
 
unstable bladder
 
Zhonglushu points