Hepatitis B and C serologic markers in blood donors of the Ribeirão Preto Blood Center

Hemocentro de Ribeirão Preto, Ribeirão Preto, SP, Brazil.
Revista da Sociedade Brasileira de Medicina Tropical (Impact Factor: 0.98). 12/2005; 38(6):488-92. DOI: 10.1590/S0037-86822005000600008
Source: PubMed


The investigation involved 25,891 blood donors who attended for the first time the Blood Center of Ribeirão Preto, Brazil, between Jun 23, 1996 and Jun 22, 2001. The objective was to study the proportion of positive serological markers for hepatitis B and C at the initial screening tests and to estimate the prevalence of such infections through the analysis of confirmatory tests, carried out at the University Hospital as a part of the patients evaluation. Data from the donors and laboratory results were obtained from the records of both the Blood Bank and the Hospital. The population of donors was mainly composed by males (83.6%) and by individuals between 26 and 45 (64%) years of age. The proportions of positive results in screening tests were 0.6% (CI95%: 0.54-0.72) for HBsAg and 1.2% (CI95%: 1.02-1.28) for anti-HCV. Confirmatory testes showed values of prevalence of 0.2% (CI95%: 0.16-0.28) for hepatitis B and 0.3% (IC95%: 0.24-0.38) for hepatitis C.

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    • "The blood unit discard rate in Brazil ranges between 10 and 20%. Infectious diseases are the main cause of this high percentage, which exceeds that of developed countries(7,8). The current research investigated the frequency of discarded blood and the prevalence of infectious-contagious diseases identified by positive serological markers in blood donors of the Regional Blood center in Maringá, Paraná, Brazil in 2011. "
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    ABSTRACT: So that an improvement in the selection of donors can be achieved and the risk to the recipient of transfused blood can be reduced, prospective donors are submitted to clinical and serological screening. This study investigated the blood discard rate and the rate of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil. This study was an exploratory cross-sectional descriptive investigation with a quantitative approach of donations between January and December 2011. In the study period the Regional Blood center in Maringá, Brazil received 8337 blood donations from people living in the city and neighboring towns. However, 278 (3.33%) donations were discarded during serological screening owing to one or more positive serological markers. A total of 46.4% of the discarded blood units were confirmed positive by serology with anti-HBc being the most common (66.7%), followed by syphilis (22.5%), HBsAg (4.7%), anti-hepatitis C virus (3.1%), human immunodeficiency virus (1.5%) and Chagas' disease (1.5%). The rate of infectious-contagious diseases that can be transmitted by blood transfusions was 1.55% (129/8337) of the donor population with a frequency of 1.03% for anti-HBc and 0.35% for syphilis. This study demonstrates a high prevalence of the anti-HBc marker in prospective blood donors from provincial towns in the state of Paraná, Brazil.
    Revista Brasileira de Hematologia e Hemoterapia 03/2013; 35(6):395-9. DOI:10.5581/1516-8484.20130126
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    • "The low HCV seroprevalence reported here is comparable to that reported in blood donors from sub- Saharan Africa [Hladik et al., 2006], and much lower than that reported in Asian blood donors [Tsatsralt-Od et al., 2005; Wiwanitkit, 2005]. However, anti-HCV seropositivity was more frequent among women in the present study, whereas no difference by gender was found in previous studies conducted among blood donors from Uganda [Hladik et al., 2006] or Brazil [Valente et al., 2005]. In contrast, HCV infection was associated with male gender in a large population-based study in the USA [Armstrong et al., 2006]. "
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    ABSTRACT: Little data are available on the seroprevalence of, and risk factors for hepatitis B and C viruses (HBV and HCV) infection in Latin American countries. A multi-center serosurvey was conducted among 3,598 first-time blood donors (65% men) from Sao Paulo, Salvador and Manaus in Brazil. The gender-specific seroprevalences of antibodies against hepatitis B core antigen (anti-HBc) and of the hepatitis B surface antigen (HBsAg) in anti-HBc-positive sera were measured, and risk factors analyzed by gender. The gender-specific seroprevalences of antibodies against HCV (anti-HCV) were measured, but risk factors for HCV were not determined. Anti-HBc and HBsAg seroprevalences were not significantly different in men [101/2,341 (4.31%) and 4/2,229 (0.18%), respectively] and women [65/1,237 (5.25%) and 8/1,169 (0.68%), respectively], whereas the seroprevalence of anti-HCV was higher in women (12/1,238 [0.97%] vs. 9/2,353 [0.38%]; odds ratio [OR] = 2.49; 95% confidence interval [CI]: 1.0-6.0). No significant difference for HBV infection was found across the three study sites or by ethnic group. The seroprevalence of anti-HBc increased with age, but decreased with education level in both genders. Lifetime number of sexual partners was associated with anti-HBc prevalence among men (OR = 1.95; 95% CI: 1.2-3.1), but not women. The seroprevalence of HBV and HCV was low among Brazilian blood donors, and exposure increased with age in both genders.
    Journal of Medical Virology 01/2008; 80(1):53-7. DOI:10.1002/jmv.21046 · 2.35 Impact Factor
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