Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older.

Center for Health Studies, Group Health Cooperative, Seattle, Washington 98101-1448, USA.
Annals of internal medicine (Impact Factor: 16.1). 02/2006; 144(2):73-81.
Source: PubMed

ABSTRACT Alzheimer disease and other dementing disorders are major sources of morbidity and mortality in aging societies. Proven strategies to delay onset or reduce risk for dementing disorders would be greatly beneficial.
To determine whether regular exercise is associated with a reduced risk for dementia and Alzheimer disease.
Prospective cohort study.
Group Health Cooperative, Seattle, Washington.
1740 persons older than age 65 years without cognitive impairment who scored above the 25th percentile on the Cognitive Ability Screening Instrument (CASI) in the Adult Changes in Thought study and who were followed biennially to identify incident dementia.
Baseline measurements, including exercise frequency, cognitive function, physical function, depression, health conditions, lifestyle characteristics, and other potential risk factors for dementia (for example, apolipoprotein E epsilon4); biennial assessment for dementia.
During a mean follow-up of 6.2 years (SD, 2.0), 158 participants developed dementia (107 developed Alzheimer disease). The incidence rate of dementia was 13.0 per 1000 person-years for participants who exercised 3 or more times per week compared with 19.7 per 1000 person-years for those who exercised fewer than 3 times per week. The age- and sex-adjusted hazard ratio of dementia was 0.62 (95% CI, 0.44 to 0.86; P = 0.004). The interaction between exercise and performance-based physical function was statistically significant (P = 0.013). The risk reduction associated with exercise was greater in those with lower performance levels. Similar results were observed in analyses restricted to participants with incident Alzheimer disease.
Exercise was measured by self-reported frequency. The study population had a relatively high proportion of regular exercisers at baseline.
These results suggest that regular exercise is associated with a delay in onset of dementia and Alzheimer disease, further supporting its value for elderly persons.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Introduction. Physical activity is associated with a decreased occurrence of dementia. In twins, we investigated the effect of persistent physical activity in adulthood on mortality due to dementia. Materials and methods. Physical activity was queried in 1975 and 1981 from the members of the older Finnish Twin Cohort (n = 21,791), who were aged 24-60 years at the end of 1981. The subjects were divided into three categories according to the persistence of their vigorous physical activity. Dementia deaths were followed up to the end of 2011. Results. During the 29-year follow-up, 353 subjects died of dementia. In individual-based analyses the age- and sex-adjusted hazard ratio (HR) was 0.65 (95% CI 0.43-0.98) for subjects partaking in vigorous physical activities in both 1975 and 1981 compared to those who were inactive in both years. No significant change was observed after adjusting for potential confounding factors. The corresponding HR for within-pair comparisons of the less active twin versus the more active co-twin was 0.48 (95% CI 0.17-1.32). The results for analyses of the volume of physical activity were inconclusive. Conclusions. Persistent vigorous leisure-time physical activity protects from dementia, and the effect appears to remain after taking into account childhood environment.
    Annals of medicine. 01/2015;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Age-related decrease in cerebral blood flow is a risk factor for cognitive decline. Aerobic exercise training improves vascular and cognitive functions. However, the effect of exercise training on age-related reduction in cerebral blood flow is unclear. The present study investigated whether aerobic exercise training can increase cerebral blood flow in postmenopausal women.Methods Twenty healthy postmenopausal women were assigned to either the exercise training group (n = 10) or the control group (n = 10). The exercise group completed 8 weeks of moderate aerobic exercise intervention. The control group did not change their physical activity level. Before and after each intervention, middle cerebral blood flow velocity and cerebrovascular resistance were measured using transcranial Doppler ultrasonography.ResultsThe baseline middle cerebral blood flow velocity, cerebrovascular resistance, and most other key dependent variables did not significantly differ between the groups. Aerobic exercise training significantly increased middle cerebral blood flow velocity and significantly decreased cerebrovascular resistance, whereas no such changes were observed in the control group.Conclusions We showed that aerobic exercise training increased middle cerebral blood flow velocity and decreased cerebrovascular resistance in postmenopausal women. The results of the current study suggest that regular aerobic exercise may attenuate aging-induced decrease in cerebral blood flow.
    Artery Research 09/2012; 6(3):124-129.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Bu derlemenin amacı, egzersizin sağlık yararları hakkında güncel bilgileri gözden geçirmektir. Rehabilitasyon hekimliğinde, ayrıntılı reçetelendirilmiş egzersiz programı en önemli modalitedir. Bu yazıda, egzersizin özellikle kardiyovasküler hastalıklar, depresyon, demans, obezite ve günlük pratiğimizde sıklıkla görülen kronik ağrı sendromları üzerine olan sağlık yararları üzerinde durulmuştur. Egzersizin bu hastalıkların önlenmesi ve tedavisindeki önemli rolü incelenip, egzersiz önerileri derlenmiştir.The purpose of this review is to provide current information concerning the health benefits of exercise. In rehabilitation medicine, a detailed prescription of the exercise program is the most important modality. In this paper, the health benefits of exercise, especially on the cardiovascular diseases, depression, dementia, obesity, and chronic pain syndrome, frequently seen in our daily practice, are emphasized. The role of exercise in the prevention and treatment of these diseases is examined, and the recommendations for exercise are reviewed.
    FTR - Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi 10/2014; 60(Supp 2):9-14. · 0.08 Impact Factor

Full-text (2 Sources)

Available from
May 21, 2014