[Show abstract][Hide abstract] ABSTRACT: Recent developments in DNA technology and computation have shifted genetic research from looking at single variants towards looking at the entirety of genomic variation. David Eccles' research explores the challenges of working with these massive genetic data sets, with an emphasis on comparing Maori and European populations from a genome-wide perspective. He identifies uniquely Maori genetic signatures in two gene regions , and derives a small set of genetic markers that reliably determine Maori-European genetic mixture in New Zealand Maori populations. Using similar genome analysis techniques to compare case and control UK populations, David’s research also derives a screening set of markers for Type 1 diabetes.
12/2010, Degree: Doctor of Philosophy in Biomedical Science, Supervisor: Rod Lea, Geoff Chambers
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