Erectile dysfunction (ED) can be an early and first sign of an underlying systemic disease. A screening program is offered by the Medical services of the Israel Defense Force for career servicemen at the Staff Periodic Examination Center (SPEC) aimed at early detection of morbidity. The Sexual Human Inventory for Males (SHIM) questionnaire was introduced to these men in order to identify ED, to offer men with ED suitable treatment options, and to investigate underlying systemic diseases.
To provide epidemiological data regarding the prevalence of ED among a large-scale young adult population.
Subjects aged 25-50 years are undergoing a routine check-up at SPEC. Blood samples, physiological measures, demographic variables, information on health status and smoking habits are recorded and documented. The SHIM self-administrated questionnaire was used to characterize ED.
During 2001-2003, 11,914 males reported to SPEC (average age 34.8 +/- 7.1 years). Five thousand eight hundred thirty-six of them chose to answer the SHIM questionnaire (compliance of 48.9%). According to the SHIM scores, at least one out of three men (26.9%) suffered from ED (19%, 7%, and 1% had mild, moderate, and severe ED, respectively). ED was prevalent also among young adults: 22.1% of males under-40 had low SHIM scores (<21). Severity of ED correlated with age and diabetes mellitus.
In light of these results, we conclude that ED is a major health concern among young men as well. Incorporating questions regarding sexual health in a routine check-up may encourage more men to seek treatment, not only for ED, but also for underlying diseases.
"Erectile dysfunction (ED) is defined as the persistent inability to achieve and maintain a sufficient erection to complete intercourse . The incidence of ED in patients less than 40 years old was 22.1%–35% , . ED is now considered as a vascular disease . "
[Show abstract][Hide abstract] ABSTRACT: Insulin resistance (IR) triggers endothelial dysfunction, which contributes to erectile dysfunction (ED) and cardiovascular disease.
To evaluate whether IR was related to ED in young adult patients.
A total of 283 consecutive men complaining of ED at least six months were enrolled, with a full medical history, physical examination, and laboratory tests collected. Quantitative Insulin Sensitivity Check Index (QUICKI) was used to determine IR. The severity of ED was assessed by IIEF-5 questionnaire. Endothelial function was assessed by ultrasonographic examination of brachial artery flow mediated dilation (FMD).
IR was detected in 52% patients. Subjects with IR had significant higher total cholesterol, triglycerides, low density lipoprotein-cholesterol (LDL-c), glycated haemoglobin (HBA1c), high sensitivity C-reactive protein (hs-CRP) and body mass index (BMI), but showed significant lower IIEF-5 score, FMD%, high density lipoprotein -cholesterol (HDL-c), testosterone, sex hormone binding globulin (SHBG) levels than patients without IR. Multiple regression analysis showed QUICKI and testosterone were independent predictors of IIEF-5 score. Furthermore, the incidence of IR was correlated with the severity of ED.
Compared with other CVFs, IR was found as the most prevalent in our subjects. Besides, IR was independently associated with ED and its severity, suggesting an adverse effect of insulin resistance on erectile function.
PLoS ONE 12/2013; 8(12):e83951. DOI:10.1371/journal.pone.0083951 · 3.23 Impact Factor
"Erectile dysfunction (ED), the inability to achieve or maintain erection, is a serious medical condition that has high impact on quality of life in 52% of men aged 40 to 70  and 22% of men under 40 . Men at high risk for ED include aging, those with diabetes and prostatectomy or radiation treatment for prostate cancer. "
[Show abstract][Hide abstract] ABSTRACT: Erectile dysfunction (ED) is a debilitating medical condition and current treatments are ineffective in patients with cavernous nerve (CN) injury, due to penile remodeling and apoptosis. A critical regulator of penile smooth muscle and apoptosis is the secreted protein sonic hedgehog (SHH). SHH protein is decreased in rat prostatectomy and diabetic ED models, SHH inhibition in the penis induces apoptosis and ED, and SHH treatment at the time of CN injury suppresses smooth muscle apoptosis and promotes regeneration of erectile function. Thus SHH treatment has significant translational potential as an ED therapy if similar mechanisms underlie ED development in patients. In this study we quantify SHH protein and morphological changes in corpora cavernosal tissue of control, prostatectomy and diabetic patients and hypothesize that decreased SHH protein is an underlying cause of ED development in prostatectomy and diabetic patients. Our results show significantly decreased SHH protein in prostatectomy and diabetic penis. Morphological remodelling of the penis, including significantly increased apoptotic index and decreased smooth muscle/collagen ratio, accompanies declining SHH. SHH signaling is active in human penis and is altered in a parallel manner to previous observations in the rat. These results suggest that SHH has significant potential to be developed as an ED therapy in prostatectomy and diabetic patients. The increased apoptotic index long after initial injury is suggestive of ongoing remodeling that may be clinically manipulatable.
PLoS ONE 08/2013; 8(8):e70985. DOI:10.1371/journal.pone.0070985 · 3.23 Impact Factor
"In many surveys, the prevalence of erectile dysfunction in the over 18 age group was found to be 4-14.7% (Laumann et al. 1999, Ventegodt 1998, Parazzini et al. 2000, Heruti et al. 2004, Fugl-meyer and Sjögren Fugl- Meyer 1999). In all the surveys, erectile dysfunction rates increase with age, in studies over age group 40 the prevalence of both moderate and severe erectile dysfunction is between 12% and 36% (Colson et al.. 2006, Lauman et al. 2005, Shirai et al. 1999, Feldman et al. 1994, Kongkanad et al. 2000, Akkus et al. 2002, Green et al. 2001, Blanker et al. 2001). "
[Show abstract][Hide abstract] ABSTRACT: Sexual problems are widely encountered in community. While studies clinically performed concerning sexual problems in Turkey exist, there are no field studies related to sexual problems witnessed in both men and women. In this study, sexual problems in married population and the level of their sexual knowledge have been tried to be investigated.
The cosmos of the study consisted of the whole married population between the ages of 18 and 60 and living in the province of Konya. Sociodemografic Information Form and Golombok-Rust Inventory of Sexual Satisfaction were performed in 945 subjects accepting to take part in the study and appropriate.
Average age rate of the males taking part in the study was 38.5+/-9.5 and the same rate of women was 34.2+/-9.8. According to the findings provided via GRISS, the rate of erectile dysfunction (ED) in men was 14.5 %, the rate of premature ejeculation (PE) 29.3 %, the rate of anorgasmia in women was found to be 5.3 %,and the rate of vaginismus to be 15.3 %.
Prevalence rates of PE, ED and anorgasmia in our sample was parallel to those provided from other countries at same age group. Vaginismus rate in our study is higher compared to other studies.
Turk psikiyatri dergisi = Turkish journal of psychiatry 06/2010; 21(2):126-34. · 0.43 Impact Factor
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