Comparative overview of brain perfusion imaging techniques

Duke University, Durham, North Carolina, United States
Journal of Neuroradiology (Impact Factor: 1.75). 01/2006; 32(5):294-314. DOI: 10.1161/01.STR.0000177839.03321.25
Source: PubMed


Numerous imaging techniques have been developed and applied to evaluate brain hemodynamics. Among these are: Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), Xenon-enhanced Computed Tomography (XeCT), Dynamic Perfusion-computed Tomography (PCT), Magnetic Resonance Imaging Dynamic Susceptibility Contrast (DSC), Arterial Spin-Labeling (ASL), and Doppler Ultrasound. These techniques give similar information about brain hemodynamics in the form of parameters such as cerebral blood flow (CBF) or volume (CBV). All of them are used to characterize the same types of pathological conditions. However, each technique has its own advantages and drawbacks. This article addresses the main imaging techniques dedicated to brain hemodynamics. It represents a comparative overview, established by consensus among specialists of the various techniques. For clinicians, this paper should offers a clearer picture of the pros and cons of currently available brain perfusion imaging techniques, and assist them in choosing the proper method in every specific clinical setting.

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    • "D'autres observations cliniques de manifestations à l'orthostatisme ou à l'effort ont motivé l'utilisation d'un test permettant de comparer la perfusion cérébrale en position couchée et lors de la mise en position debout. Parmi les différentes méthodes d'examen de la perfusion cérébrale [3], la seule à pouvoir renseigner sur la perfusion en position debout est la scintigraphie de perfusion. En effet, les traceurs de perfusion liposolubles utilisés bénéficient d'une fraction d'extraction suffisante au premier passage pour que des images réalisées plusieurs minutes après injection reflètent les conditions de perfusion au moment de l'injection. "
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