Hairy cell leukemia: A diagnosis by endoscopic ultrasound guided fine needle aspiration

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
CytoJournal 02/2006; 3:1. DOI: 10.1186/1742-6413-3-1
Source: PubMed


Endosonography (EUS) guided FNA is a relatively new imaging modality which is increasingly used for sampling deep-seated lymph nodes in the diagnosis and staging of various malignancies, both primary as well as metastatic. It is also useful for staging of non-Hodgkin's lymphoma as well as diagnosing recurrence. The diagnosis of leukemia on FNA samples from deep-seated lymphadenopathy poses an even greater challenge. Hairy cell leukemia (HCL) is an uncommon, but distinct, lympho-proliferative disorder of B cell origin. It usually affects the spleen and bone marrow and uncommonly involves lymph nodes. There are only a few cases reported where HCL was diagnosed on FNA specimens.
We report the first case of HCL accurately rendered on EUS-FNA samples.
This report underscores the concept that the presence of a cytopathologist in the endoscopy suite plays an important role in providing accurate diagnoses of lymphoid lesions biopsied with EUS-FNA.

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