Kikuchi-Fujimoto disease: A rare but important cause of fever and lymphadenopathy in pregnant women

Department of Hematology-Oncology, Erciyes Üniversitesi, Melikgazi, Kayseri, Turkey
American Journal of Hematology (Impact Factor: 3.8). 02/2006; 81(2):118-20. DOI: 10.1002/ajh.20495
Source: PubMed


We report a case of Kikuchi-Fujimoto disease (KFD) in a 28-year-old pregnant woman with prolonged fever and generalized lymphadenopathy. We evaluated the patient for etiology of the fever and adenopathy, which were unresponsive to antibiotic therapy. Cervical lymph node histology showed KFD. Currently, there is scant data available regarding the course and treatment of KFD during pregnancy. We administered steroid therapy (prednisone 1 mg/kg/day) to control severe systemic and constitutional symptoms. We observed a reduction in lymph node size as well as abatement of fever and other constitutional symptoms. The patient carried the fetus to full term with no apparent adverse effect. Our experience showed that steroid therapy may be used effectively to control KFD-related symptoms after the first 16 weeks without terminating the pregnancy.

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    • "Some authors emphasise the role of immunological mechanisms involved in the pathogenesis of KFD and consider this disease as a rare manifestation of systemic lupus erythematosus (SLE). Previous literature on KFD frequently addressed the link between KFD and SLE, and the reported rate was 1.3% to 7% in the population of KFD patients [5] [6] [11]. Clinically and histologically KFD can be mistaken for SLE or, more important, for malignant lymphoma. "
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    ABSTRACT: Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a benign and self-limited disease, characterized typically by enlargement of regional lymph nodes accompanied by fever. KFD affects predominantly young adult females of Asian origin and is rarely seen in European countries, where it may cause diagnostic difficulties. Two cases of KFD in a 33 and 27-year-old woman with mild fever, malaise, lymphadenopathy initially misdiagnosed for indolent non-Hodgkin's lymphoma was presented. The definitive diagnosis was established on the basis of histopathological examination of totally excised cervical lymph nodes. The propriety diagnosis allowed us to avoid inappropriate chemotherapy. The disease course in our patient was uneventful during the 1.5 and 12-year follow-up period. The clinical presentations, complications as well as current concepts on pathogenesis, diagnosis and treatment of the Kikuchi-Fujimoto disease was briefly reviewed in this paper. The need of a long-term follow-up of patients with Kikuchi-Fujimoto disease was emphasized.
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    ABSTRACT: We report a case of Kikuchi Fujimoto disease in a 34-y-old woman, with emphasis on the clinical picture and pathologic findings.
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    ABSTRACT: We describe a 20-year-old woman with autoimmune hepatitis (AIH) with cirrhosis who developed Kikuchi-Fujimoto's disease (KFD) and de novo minor features of systemic lupus erythematosus (SLE). This is the first report of a patient with histologically confirmed AIH developing KFD (histiocytic necrotizing lymphadenitis). One previous case described KFD after AIH (diagnosed clinically but without biopsy). KFD is a rare condition of unknown aetiology, first described in 1972, characterized by fever and cervical adenopathy and has a self-limiting course. KFD is associated with SLE, and SLE in turn can be associated with abnormal liver function tests, which in a minority of cases may be due to AIH. The association of AIH, KFD, and SLE in our patient suggests an autoimmune pathogenesis of KFD.
    European Journal of Gastroenterology & Hepatology 02/2008; 20(1):79-82. DOI:10.1097/MEG.0b013e32825a6a9e · 2.25 Impact Factor
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