The Implantable Miniature Telescope for macular degeneration.
ABSTRACT The function is described of the Implantable Miniature Telescope, which is completing clinical development for bilateral end-stage macular degeneration, and 6-month results of the Phase II/III IMT002 prospective, multicenter study are presented. Multispecialty patient management and implications of the study's findings are discussed.
No medical treatments are currently available for bilateral end-stage age-related macular degeneration (atrophic or disciform scar age-related macular degeneration). The visual prosthetic device discussed in this update is implanted in the posterior chamber to reduce the impact of the scotomata on the patient's central vision. The goal of treatment is to improve the patient's ability to perform everyday activities and participate in roles and hobbies that impact their quality of life. Patients implanted with the device experienced clinically significant gains in visual acuity and quality of life at 6 months. In total, 89% gained two or more lines of best-corrected near or distance visual acuity. The device was generally safe and well tolerated. The surgical technique is important to minimize surgically related reduction in endothelial cell density.
This age-related macular degeneration visual prosthesis has been shown to improve visual acuity and quality of life for the bilateral end-stage age-related macular degeneration patient population that at present has no other acceptable options. Endothelial cell density from baseline to 6 and 12 months after device implantation was reduced due to trauma from the surgical procedure, but was compatible with a healthy cornea. Meticulous surgical technique and a comprehensive, multispecialty approach to preoperative and postoperative patient management are essential for successful outcomes.
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ABSTRACT: A novel multifunctional and biocompatible ultrananocrystalline diamond (UNCD) film technology developed recently represents a new material with a unique combination of functionalities, including biocompatibility, to enable a new generation of implantable medical devices and scaffolds for tissue engineering. Following a description of the synthesis and properties of UNCD films and a comparison with other diamond film technologies, this article focuses on descriptions of key UNCD-based medical devices to treat specific medical conditions requiring effective therapies: (1) A UNCD-coated microchip (artificial retina) implantable inside the eye on the retina to restore partial vision to people blinded by retinitis pigmentosa and macular degeneration produced by genetically induced degeneration of the retina photoreceptors. (2) A UNCD-coated intraocular device for treatment of glaucoma in the eye. (3) UNCD-coated metal dental implants with potential order of magnitude longer life and superior performance than current implants.MRS Bulletin 07/2014; 39(07):621-629. DOI:10.1557/mrs.2014.134 · 5.07 Impact Factor
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ABSTRACT: Optical system design is always constrained by achievable fabrication tolerances, and there is a constant balance between design performance and the cost or yield of the fabrication process. However, many of the best designs are achieved by starting from the manufacturing platform, and modifying the basic structure of the system to take maximum advantage of symmetries in the system. We will describe several optical systems whose symmetries have allowed us to bypass some of the more problematic tolerances. The first is a multi-reflection imaging system using concentric aspheric mirrors, diamond turned into a a single optical element, which allowed us to create a 3x magnification Galilean telescope just 1 mm thick, designed to be incorporated into a contact lens as a vision aid. The second system is a multi-scale lens design which explores a different type of symmetry: a bilateral monocentric primary lens, followed by over 200 identical secondary optics, which together form an aggregate 2500 megapixel imager. And the third system is a non-imaging solar concentrator using micro-optic lenslets and micro-reflectors which couple incident sunlight into a slab waveguide, where the problem of aligning the lenslets to the micro-reflectors has been bypassed by using the focal spot from each lenslet to form it's corresponding injection feature.SPIE Optical Engineering + Applications; 09/2011
Article: Telescopic Vision Contact Lens[Show abstract] [Hide abstract]
ABSTRACT: We present the concept, optical design, and first proof of principle experimental results for a telescopic contact lens intended to become a visual aid for age-related macular degeneration (AMD), providing magnification to the user without surgery or external head-mounted optics. Our contact lens optical system can provide a combination of telescopic and non-magnified vision through two independent optical paths through the contact lens. The magnified optical path incorporates a telescopic arrangement of positive and negative annular concentric reflectors to achieve 2.8x - 3x magnification on the eye, while light passing through a central clear aperture provides unmagnified vision.Proceedings of SPIE - The International Society for Optical Engineering 02/2011; DOI:10.1117/12.878795 · 0.20 Impact Factor