Olfactory stimulation with scent of lavender oil affects autonomic neurotransmission and blood pressure in rats.
ABSTRACT Previously, we observed that olfactory stimulation with scent of lavender oil (SLVO) suppressed sympathetic nerve activities and elevated gastric vagal (parasympathetic) nerve activity (GVNA), decreased plasma glycerol concentration and body temperature, and enhanced appetite in rats. Here, we further showed that olfactory stimulation with SLVO lowered renal sympathetic nerve activity (RSNA) and blood pressure (BP) and elevated GVNA in urethane-anesthetized rats. Olfactory stimulation with linalool, a component of lavender oil, also elicited decreases in RSNA and BP and an increase in GVNA in urethane-anesthetized rats. Anosmia induced by pretreatment of the nasal cavity by application of ZnSO4 eliminated the effects of both SLVO and scent of linalool on RSNA, GVNA and BP. Furthermore, intracerebroventricular administration of thioperamide, a histaminergic H3-antagonist, abolished the suppression of RSNA and BP as well as the elevation of GVNA mediated by both SLVO and scent of linalool. Finally, bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) eliminated RSNA and BP suppression and the elevation of GVNA due to SLVO or linalool. Thus, it was concluded that scent of lavender oil and its active component, linalool, affects autonomic neurotransmission and reduces blood pressure through the central histaminergic nervous system and the SCN.
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ABSTRACT: We reviewed studies from 2000 to 2008 on using essential oils for patients with depression or depressive symptoms and examined their clinical effects. The review was conducted among five electronic databases to identify all peer-reviewed journal papers that tested the effects of aromatherapy in the form of therapeutic massage for patients with depressive symptoms. The results were based on six studies examining the effects of aromatherapy on depressive symptoms in patients with depression and cancer. Some studies showed positive effects of this intervention among these three groups of patients. We recommend that aromatherapy could continue to be used as a complementary and alternative therapy for patients with depression and secondary depressive symptoms arising from various types of chronic medical conditions. More controlled studies with sound methodology should be conducted in the future to ascertain its clinical effects and the underlying psychobiologic mechanisms.Journal of alternative and complementary medicine (New York, N.Y.) 03/2009; 15(2):187-95. · 1.69 Impact Factor
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ABSTRACT: Here, we examined the effects of auditory stimulation at 50 dB with white noise (WN) or music (Traeumerei [TM] by Schumann or Etude by Chopin) on renal sympathetic nerve activity (RSNA) and BP in urethane-anesthetized rats. Auditory stimulation with TM, but not with WN or the Etude, significantly decreased RSNA and BP. Complete bilateral destruction of the cochleae and bilateral lesions of the auditory cortex (AuC) eliminated the effects of TM stimulation on RSNA and BP, but bilateral lesions of primary somatosensory cortex (S1C) had no effect. Bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) or intracerebral administration of thioperamide, a histaminergic H3 receptor antagonist, also abolished TM-induced decreases in RSNA and BP. These findings suggest that exposure to music can decrease RSNA and BP through the auditory pathway, histaminergic neurons, and the SCN.Neuroscience Letters 05/2007; 416(2):107-12. · 2.11 Impact Factor