Population-based case-control study of allergic rhinitis during pregnancy for birth outcomes

Department of Respiratory Medicine, School of Medicine, Semmelweis University, Budapest, Hungary. <>
European Journal of Obstetrics & Gynecology and Reproductive Biology (Impact Factor: 1.7). 04/2007; 131(1):21-7. DOI: 10.1016/j.ejogrb.2005.11.035
Source: PubMed


Allergic rhinitis is frequent in women of childbearing age including pregnancy. The present study aimed to estimate the effect of maternal allergic rhinitis on birth outcomes, in particular congenital abnormalities, preterm birth and low birthweight newborns.
Analysis of the population-based data of the Hungarian Case-Control Surveillance of Congenital Abnormalities between 1980 and 1996.
The evaluation of data did not reveal any teratogenic potential of allergic rhinitis and indeed a lower prevalence of total congenital abnormalities was found. In addition, a protective effect could be observed for preterm birth due to longer gestational age (adjusted t=2.97, p=0.003).
Allergic rhinitis is not risk factor for pregnant women.

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Available from: Akos Somoskövi,
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    • "Corticosteroids also induce dysregulation of placental hormone/cytokine gene expression and downregulation of the insulin-like growth factor-II/Akt signaling pathway, which may result in increased placental apoptosis, placental insufficiency, and fetal growth restriction (32). Although some studies showed that the prevalence of allergic rhinitis was lower in mothers of extremely LBW ( < 1,000 g) pre-term infants compared with mothers of full-term babies (33), others reported no association between maternal allergic rhinitis during pregnancy and BW (27). The association between maternal allergic disease and BW of infant may be explained by the Developmental Origins of Health and Disease (DOHaD) theory (34). "
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    ABSTRACT: Previous studies suggest that maternal characteristics may be associated with neonatal outcomes. However, the influence of maternal characteristics on birth weight (BW) has not been adequately determined in Korean populations. We investigated associations between maternal characteristics and BW in a sample of 813 Korean women living in the Seoul metropolitan area, Korea recruited using data from the prospective hospital-based COhort for Childhood Origin of Asthma and allergic diseases (COCOA) between 2007 and 2011. The mean maternal age at delivery was 32.3 ± 3.5 yr and prepregnancy maternal body mass index (BMI) was 20.7 ± 2.5 kg/m(2). The mean BW of infant was 3,196 ± 406 g. The overall prevalence of a maternal history of allergic disease was 32.9% and the overall prevalence of allergic symptoms was 65.1%. In multivariate regression models, prepregnancy maternal BMI and gestational age at delivery were positively and a maternal history of allergic disease and nulliparity were negatively associated with BW (all P < 0.05). Presence of allergic symptoms in the mother was not associated with BW. In conclusion, prepregnancy maternal BMI, gestational age at delivery, a maternal history of allergic disease, and nulliparity may be associated with BW, respectively.
    Journal of Korean medical science 04/2013; 28(4):580-5. DOI:10.3346/jkms.2013.28.4.580 · 1.27 Impact Factor
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    • "In accordance with the finding that allergic disease is associated with shorter waiting time to pregnancy73,74, higher birth weight and less preterm births89,90, it has also been suggested that the Th2-like immunity associated with allergic disease could promote a development of Th2 immune responses in the offspring 91. "
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    ABSTRACT: Early genetic and environmental factors have been discussed as potential causes for the high prevalence of asthma and allergic disease in the western world, and knowledge on fetal growth and its consequence on future health and disease development is emerging. This review article is an attempt to summarize research on fetal growth and risk of asthma and allergic disease. Current knowledge and novel findings will be reviewed and open research questions identified, to give basic scientists, immunologists and clinicians an overview of an emerging research field. PubMed-search on pre-defined terms and cross-references. Several studies have shown a correlation between low birth weight and/or gestational age and asthma and high birth weight and/or gestational age and atopy. The exact mechanism is not yet clear but both environmental and genetic factors seem to contribute to fetal growth. Some of these factors are confounders that can be adjusted for, and twin studies have been very helpful in this context. Suggested mechanisms behind fetal growth are often linked to the feto-maternal circulation, including the development of placenta and umbilical cord. However, the causal link between fetal growth restriction and subsequent asthma and allergic disease remains unexplained. New research regarding the catch-up growth following growth restriction has posited an alternative theory that diseases later on in life result from rapid catch-up growth rather than intrauterine growth restriction per se. Several studies have found a correlation between a rapid weight gain after birth and development of asthma or wheezing in childhood. Asthma and allergic disease are multifactorial. Several mechanisms seem to influence their development. Additional studies are needed before we fully understand the causal links between fetal growth and development of asthma and allergic diseases.
    Clinical & Experimental Allergy 10/2012; 42(10):1430-47. DOI:10.1111/j.1365-2222.2012.03997.x · 4.77 Impact Factor
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    • "Allergic disease is associated with shorter waiting time to pregnancy (Westergaard et al. 2003), longer gestational age, higher birth weight (Somoskovi et al. 2007) and less pre-term births (Savilahti et al. 2004). Thus, the Th2-like immunity associated with allergic disease might generate favourable effects on the likelihood of being pregnant and the maintenance of pregnancy. "
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    ABSTRACT: Type 2 T-helper cell (Th2)-skewed immunity is associated with successful pregnancy and the ability to easily direct immune responses to a Th2-polarised profile may be an evolutionary benefit. The Th2-like immunity associated with allergic disease might generate favourable effects for the maintenance of pregnancy, but could also promote development of Th2-like immune responses and allergic disease in the offspring. The aim of this study was to explore, by using IgE as a stable proxy for Th2, the Th1/Th2 balance in allergic and non-allergic women by measuring allergen-specific and total IgE antibody levels in plasma during pregnancy and after delivery. Specific and total IgE antibody levels were determined by ImmunoCAP technology at five occasions during pregnancy (gestational weeks 10-12, 15-16, 25, 35 and 39), as well as at 2 and 12 months after delivery. Thirty-six women without and 20 women with allergic symptoms were included, of whom 13 were sensitised with allergic symptoms and 30 were non-sensitised without allergic symptoms. The levels of total IgE, but not allergen-specific IgE, were increased during early pregnancy when compared to 12 months after delivery in the sensitised women with allergic symptoms, but not in the non-sensitised women without allergic symptoms (p<0.01). This increase in total IgE levels during early pregnancy only in the sensitised women with allergic symptoms indicates that allergy is associated with an enhanced Th2 deviation during pregnancy.
    Journal of Reproductive Immunology 06/2009; 81(1):82-8. DOI:10.1016/j.jri.2009.04.003 · 2.82 Impact Factor
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